Hunter Medical Research Institute, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW 2305, Australia.
Viruses. 2022 Jan 13;14(1):141. doi: 10.3390/v14010141.
Rhinoviruses (RVs) have been reported as one of the main viral causes for severe respiratory illnesses that may require hospitalization, competing with the burden of other respiratory viruses such as influenza and RSV in terms of severity, economic cost, and resource utilization. With three species and 169 subtypes, RV presents the greatest diversity within the Enterovirus genus, and despite the efforts of the research community to identify clinically relevant subtypes to target therapeutic strategies, the role of species and subtype in the clinical outcomes of RV infection remains unclear. This review aims to collect and organize data relevant to RV illness in order to find patterns and links with species and/or subtype, with a specific focus on species and subtype diversity in clinical studies typing of respiratory samples.
鼻病毒（RV）已被报道为导致严重呼吸道疾病的主要病毒之一，这些疾病可能需要住院治疗，其严重程度可与流感和 RSV 等其他呼吸道病毒相媲美，无论是在严重程度、经济成本还是资源利用方面。RV 是肠道病毒属中具有最大多样性的病毒，有三个种和 169 个亚型，尽管研究界努力鉴定出具有临床相关性的亚型以针对治疗策略，但 RV 感染的临床结果与种和/或亚型的关系仍不清楚。本综述旨在收集和整理与 RV 疾病相关的数据，以发现与种和/或亚型相关的模式和联系，特别关注临床研究中呼吸道样本分型的种和亚型多样性。
