被选择用于抵抗肿瘤坏死因子的非造血细胞会产生肿瘤坏死因子。
Nonhematopoietic cells selected for resistance to tumor necrosis factor produce tumor necrosis factor.
作者信息
Rubin B Y, Anderson S L, Sullivan S A, Williamson B D, Carswell E A, Old L J
出版信息
J Exp Med. 1986 Oct 1;164(4):1350-5. doi: 10.1084/jem.164.4.1350.
Abstract
TNF-resistant lines of L cells can be derived from TNF-sensitive populations by repeated exposure to TNF, and these resistant L cells, in contrast to sensitive L cells and other types of cells, lack demonstrable cell surface receptors for TNF. We have now found that TNF-resistant L cells produce a factor that is cytotoxic for L cells and has the following distinguishing characteristics of mouse TNF: it is a protein of 43 kD, composed of 16 kD subunits, that competes with TNF for receptor binding, induces hemorrhagic necrosis of the TNF-sensitive mouse sarcoma Meth A, has synergistic cytotoxic action with interferon, and its activity is neutralized by antibody to TNF. The two conclusions of this study are that cells selected for TNF resistance spontaneously produce a molecule resembling macrophage TNF, and that cells of nonhematopoietic origin are capable of producing TNF.
摘要
L细胞的肿瘤坏死因子（TNF）抗性系可通过反复暴露于TNF从TNF敏感群体中获得，与敏感L细胞和其他类型的细胞相比，这些抗性L细胞缺乏可证明的TNF细胞表面受体。我们现已发现，TNF抗性L细胞产生一种对L细胞具有细胞毒性的因子，该因子具有小鼠TNF的以下显著特征：它是一种43kD的蛋白质，由16kD亚基组成，能与TNF竞争受体结合，诱导TNF敏感的小鼠肉瘤Meth A发生出血性坏死，与干扰素具有协同细胞毒性作用，其活性可被抗TNF抗体中和。本研究的两个结论是，因TNF抗性而被选择的细胞自发产生一种类似于巨噬细胞TNF的分子，并且非造血起源的细胞能够产生TNF。
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