Independent regulation of the antiviral states induced by MuIFN-alpha/beta and by MuIFN-gamma.

The stability profiles of the antiviral states induced in L-929 cells against mengovirus by murine interferons MuIFN-alpha/beta and by MuIFN-gamma were shown to be different. Treatment of cells with combinations of IFN-alpha/beta and IFN-gamma have previously been shown to result in a potentiated expression of the antiviral state. Here we report studies of the stabilities of the antiviral states induced by various combinations of IFN-alpha/beta and IFN-gamma and that the regulation of the antiviral states induced by IFN-alpha/beta and IFN-gamma were independent of each other.