From the Nellis Family Medicine Residency, Nellis AFB, NV.
J Am Board Fam Med. 2018 Sep-Oct;31(5):809-811. doi: 10.3122/jabfm.2018.05.180024.
We present a report of cinnamon bark powder 1000 mg daily associated with edema that resolved after stopping the supplement in an adult male. Thiazolidinediones (TZDs) cause fluid retention in those with diabetes or prediabetes. Some medications in this class have been implicated in increased cardiac deaths from this side effect. While medications are effective for diabetes, many people have turned to natural remedies to treat their diabetes instead of conventional pharmaceuticals. Cinnamon is a common agent used, and it has received extensive lay press attention. Chemically, cinnamon bark powder activates peroxisome proliferated activated receptors similar to TZDs. It is reasonable to hypothesize that cinnamon bark powder can cause edema. This case demonstrates that cinnamon bark powder may have a similar side effect profile. Physicians should be aware that consumption of cinnamon bark powder could cause fluid retention and possibly worsen congestive heart failure.
我们报告了一例每日服用 1000 毫克肉桂皮粉导致水肿的病例，该病例在停止服用该补充剂后得到缓解。噻唑烷二酮类药物（TZDs）会导致糖尿病或糖尿病前期患者体内液体潴留。该类药物中的一些药物已被怀疑会因这种副作用导致心脏死亡增加。虽然这些药物对糖尿病有效，但许多人已经转向天然药物来治疗糖尿病，而不是使用传统药物。肉桂是一种常用的药物，它受到了广泛的媒体关注。从化学角度来看，肉桂皮粉可激活过氧化物酶体增殖物激活受体，类似于 TZDs。因此可以合理地假设肉桂皮粉可能会引起水肿。本病例表明，肉桂皮粉可能具有类似的副作用谱。医生应注意，肉桂皮粉的摄入可能会导致液体潴留，并可能使充血性心力衰竭恶化。
