3,4-二羟基苯乙胺和去甲肾上腺素在犬脾脏和肾脏终末交感神经中的囊泡储存。
Vesicular storage of 3,4-dihydroxyphenylethylamine and noradrenaline in terminal sympathetic nerves of dog spleen and kidney.
作者信息
Muller B D, Bell C
出版信息
J Neurochem. 1986 Nov;47(5):1370-5. doi: 10.1111/j.1471-4159.1986.tb00767.x.
The subcellular distribution of 3,4-dihydroxyphenylethylamine (DA, dopamine) and noradrenaline was examined in preparations of dog spleen and renal cortex following ultracentrifugation on a discontinuous sucrose gradient. In both tissues, only half the total tissue DA was localized to the soluble phase, and 30-50% was found in association with noradrenaline in the large vesicular fraction, suggesting that both catecholamines may be stored together and released by nerve stimulation. The vesicular fraction from renal cortex contained more DA than could be attributed to its presence in noradrenergic axons alone, supporting other evidence for the existence of dopaminergic renal nerves.
在狗脾脏和肾皮质制剂中，经不连续蔗糖梯度超速离心后，研究了3,4-二羟基苯乙胺（DA，多巴胺）和去甲肾上腺素的亚细胞分布。在这两种组织中，仅一半的组织总DA定位于可溶性部分，30 - 50%与大囊泡部分中的去甲肾上腺素相关，这表明两种儿茶酚胺可能一起储存并通过神经刺激释放。肾皮质的囊泡部分所含的DA比仅存在于去甲肾上腺素能轴突中的量更多，这支持了多巴胺能肾神经存在的其他证据。
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