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Restricted Mean Survival Time: An Obligatory End Point for Time-to-Event Analysis in Cancer Trials?受限平均生存时间：癌症试验中事件发生时间分析的必要终点？
J Clin Oncol. 2016 Oct 1;34(28):3474-6. doi: 10.1200/JCO.2016.67.8045. Epub 2016 Aug 9.
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The Net Chance of a Longer Survival as a Patient-Oriented Measure of Treatment Benefit in Randomized Clinical Trials.作为随机临床试验中治疗效益的一种以患者为中心的衡量指标，净生存机会。
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当比例风险假设不成立时，累积模式和随访持续时间如何影响危害比的估计？

How Do the Accrual Pattern and Follow-Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated?

机构信息

Department of Clinical Medicine (Biostatistics), Kitasato University Graduate School of Pharmaceutical Sciences, Tokyo, Japan.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

出版信息

Oncologist. 2019 Jul;24(7):867-871. doi: 10.1634/theoncologist.2018-0141. Epub 2018 Sep 10.

DOI:10.1634/theoncologist.2018-0141
PMID:30201741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6656438/
Abstract

In randomized clinical trials, the magnitude of the treatment effect is often reported using the hazard ratio (HR) even when the proportional hazards (PH) assumption is not met. Conducting numerical studies, this commentary illustrates how/why the HR estimate via the standard Cox's procedure is difficult to interpret even as an “average” treatment effect for non‐PH cases.

摘要

在随机临床试验中，即使不符合比例风险（PH）假设，也常使用风险比（HR）来报告治疗效果的大小。通过数值研究，本评论说明了即使对于非 PH 情况，标准 Cox 程序的 HR 估计值作为“平均”治疗效果也很难解释。