Aghili Kazem, Sobhan Mohammad Reza, Mehdinezhad-Yazdi Masoud, Jafari Mohammadali, Miresmaeili Seyed Mohsen, Rastegar Shohreh, Mazaheri Mahta, Neamatzadeh Hossein
Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
J Orthop. 2018 Aug 24;15(4):945-951. doi: 10.1016/j.jor.2018.08.033. eCollection 2018 Dec.
To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted.
A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018.
The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques.
The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.
为评估生长分化因子5(GDF-5)基因rs143383多态性与影像学诊断的膝关节骨关节炎(OA)之间的关联,进行了一项系统评价和荟萃分析。
截至2018年6月,从多个电子数据库中收集了17项相关病例对照研究,共7424例病例和11310例对照。
汇总结果显示,在总体分析以及按种族、对照来源和基因分型技术进行的分层分析中,GDF-5基因rs143383多态性与影像学诊断的膝关节OA显著相关。
GDF-5基因rs143383多态性可能用作影像学诊断膝关节OA的相关风险评估指标。