肿瘤坏死因子-α -308G>A和-238G>A基因多态性与膝骨关节炎风险的关联：一项病例对照研究和荟萃分析
Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis.
作者信息
Sobhan Mohammad Reza, Mahdinezhad-Yazdi Masoud, Aghili Kazem, Zare-Shehneh Masoud, Rastegar Shohreh, Sadeghizadeh-Yazdi Jalal, Neamatzadeh Hossein
机构信息
Department of Orthopedics, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Orthopedics, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
J Orthop. 2018 May 9;15(3):747-753. doi: 10.1016/j.jor.2018.05.047. eCollection 2018 Sep.
Abstract
OBJECTIVE
A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA).
METHODS
Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified.
RESULTS
Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found.
CONCLUSION
This meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and -238G > A polymorphisms may not be associated with the susceptibility to knee OA.
摘要
目的
通过对电子数据库进行全面检索，以识别所有符合条件的关于肿瘤坏死因子-α（TNF-α）基因多态性与膝关节骨关节炎（OA）的研究。
方法
确定了8项关于TNF-α -308 G>A的研究以及3项关于TNF-α -238G>A多态性的研究。
结果
总体而言，合并后的比值比表明，TNF-α -238G>A和-238G>A多态性均与膝关节OA风险无关。同样，在按种族进行的分层分析中，未发现显著关联。
结论
本荟萃分析结果与之前的荟萃分析不一致，表明TNF-α -308 G>A和-238G>A多态性可能与膝关节OA易感性无关。
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