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人乳头瘤病毒作为妇科和口咽癌病因学因素的影响

The Impact of HPV as an Etiological Factor in Gynecological and Oropharyngeal Cancer.

作者信息

Mañon Rafael, Schimp Veronica, Gopalan Priya, Pattani Kavita, Tseng Jennifer

机构信息

University of Florida Health, Orlando Health, Orlando, Florida (RM, VS, KP, JT).

University of Florida Health, Shands Hospital, Gainesville, Florida (PG).

出版信息

Am J Lifestyle Med. 2015 Feb 12;10(4):253-261. doi: 10.1177/1559827615569707. eCollection 2016 Jul-Aug.

DOI:10.1177/1559827615569707
PMID:30202280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6125059/
Abstract

The human papilloma virus (HPV) is one of several viral pathogens linked to human cancer. This article reviews the current worldwide cancer burden related to this pathogen. The article also examines the role of HPV in oropharyngeal and gynecological malignancies, current treatment implications, and future directions in the treatment and prevention of HPV-related disease.

摘要

人乳头瘤病毒(HPV)是与人类癌症相关的几种病毒病原体之一。本文综述了目前全球与该病原体相关的癌症负担。文章还探讨了HPV在口咽和妇科恶性肿瘤中的作用、当前的治疗意义以及HPV相关疾病治疗和预防的未来方向。

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本文引用的文献

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Epidemiology of HPV-associated oropharyngeal cancer.人乳头瘤病毒相关口咽癌的流行病学
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Epidemiology of oral human papillomavirus infection.口腔人乳头瘤病毒感染的流行病学
Oral Oncol. 2014 May;50(5):364-9. doi: 10.1016/j.oraloncology.2013.09.003. Epub 2013 Sep 27.
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Prevalence of and risk factors for oral human papillomavirus among young women in Costa Rica.哥斯达黎加年轻女性口腔人乳头瘤病毒感染的流行率及其危险因素。
J Infect Dis. 2013 Nov 15;208(10):1643-52. doi: 10.1093/infdis/jit369. Epub 2013 Sep 6.
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Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica.在哥斯达黎加进行的一项随机临床试验中,二价 HPV 疫苗接种 4 年后,口腔 HPV(人乳头瘤病毒)的流行率降低。
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Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma.HPV 相关口咽鳞状细胞癌患者的长期预后和危险因素。
Cancer. 2013 Oct 1;119(19):3462-71. doi: 10.1002/cncr.28250. Epub 2013 Jul 16.
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Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer.评估人乳头瘤病毒抗体与头颈部癌症后续发病风险的关系。
J Clin Oncol. 2013 Jul 20;31(21):2708-15. doi: 10.1200/JCO.2012.47.2738. Epub 2013 Jun 17.
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Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer.人乳头瘤病毒治疗性疫苗:以病毒抗原为靶点的免疫疗法治疗癌前病变和癌症。
Expert Rev Vaccines. 2013 Mar;12(3):271-83. doi: 10.1586/erv.13.23.
9
Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes.头颈部癌症的分子亚型表现出典型癌症基因的染色体获得和丢失的不同模式。
PLoS One. 2013;8(2):e56823. doi: 10.1371/journal.pone.0056823. Epub 2013 Feb 22.
10
Impact of HPV-related head and neck cancer in clinical trials: opportunity to translate scientific insight into personalized care.人乳头瘤病毒相关头颈癌在临床试验中的影响:将科学见解转化为个性化医疗的契机
Otolaryngol Clin North Am. 2012 Aug;45(4):795-806. doi: 10.1016/j.otc.2012.04.002. Epub 2012 May 30.