Lafaurie Gloria I, Perdomo Sandra J, Buenahora María R, Amaya Sandra, Díaz-Báez David
Unit of Basic Oral Investigation, School of Dentistry, El Bosque University, Bogotá, Colombia.
Unit of Oral Clinical Epidemiology, School of Dentistry, El Bosque University, Bogotá, Colombia.
J Investig Clin Dent. 2018 May;9(2):e12313. doi: 10.1111/jicd.12313. Epub 2018 Jan 10.
The increasing prevalence of human papilloma virus (HPV)-positive oral tumors can be considered an epidemic. Although the incidence of HPV cervical cancer is decreasing, the incidence of oral cavity and oropharyngeal cancers associated with HPV is increasing. The presence of certain HPV genotypes could be a predictor of future oral cancer lesions, although lesions associated with HPV could be less aggressive and exhibit a higher survival rate. In the present study, we review the most important biologic, clinic, epidemiologic, and prognostic factors associated with HPV infection and oral cancer.
人乳头瘤病毒（HPV）阳性口腔肿瘤患病率的不断上升可被视为一种流行病。尽管HPV宫颈癌的发病率在下降，但与HPV相关的口腔和口咽癌的发病率却在上升。某些HPV基因型的存在可能是未来口腔癌病变的一个预测指标，尽管与HPV相关的病变可能侵袭性较小且生存率较高。在本研究中，我们综述了与HPV感染和口腔癌相关的最重要的生物学、临床、流行病学和预后因素。
