Center of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.
Department of Orthopaedic Surgery, Saarland University Medical Center, Kirrberger Strasse 100, Building 37, 66421, Homburg/Saar, Germany.
Knee Surg Sports Traumatol Arthrosc. 2019 Jun;27(6):1939-1942. doi: 10.1007/s00167-018-5136-7. Epub 2018 Sep 10.
Possible failures of autologous chondrocyte implantation (ACI), a cell-based technique for articular cartilage repair, are not always clinically apparent and the underlying mechanisms largely remain unknown. This case report presents the first scenario in the literature highlighting an association of a medium-term partial failure of an advanced ACI procedure (matrix-assisted ACI) in the knee with focal asymptomatic calcium pyrophosphate deposition disease, a common inflammatory pyrophosphate arthropathy. The specific presence of CPPDs, resulting from increased biomechanical stresses in the repair tissue-cartilage and repair tissue-subchondral bone integration sites, together with the absence of cartilage regeneration was identified and possibly contributed to the partial failure.Level of evidence V.
自体软骨细胞移植（ACI）是一种用于关节软骨修复的细胞技术，其可能的失败并不总是在临床上表现出来，其潜在机制在很大程度上仍然未知。本病例报告首次提出了一种中期部分失败的先进 ACI 手术（基质辅助 ACI）与膝关节中焦无症状焦磷酸钙沉积病（一种常见的炎症性焦磷酸盐关节病）之间的关联。在修复组织-软骨和修复组织-软骨下骨整合部位，由于生物力学应力增加，存在特定的 CPPD，同时没有软骨再生，这被认为可能是部分失败的原因。证据水平 V。
