From the Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
Fielding School of Public Health, University of California at Los Angeles, Los Angeles, CA.
Sex Transm Dis. 2018 Oct;45(10):660-665. doi: 10.1097/OLQ.0000000000000845.
Men who have sex with men (MSM) are at risk for cancers attributable to human papillomavirus (HPV), including oropharyngeal cancer. Human papillomavirus vaccination is recommended for US MSM through age 26 years. Oral HPV infection is associated with oropharyngeal cancer. We determined oral HPV prevalence and risk factors among young MSM.
The Young Men's HPV study enrolled MSM aged 18 through 26 years from clinics in Chicago and Los Angeles during 2012 to 2014. Participants self-reported demographics, sexual behaviors, vaccination and human immunodeficiency virus (HIV) status. Self-collected oral rinse specimens were tested for HPV DNA (37 types) by L1-consensus PCR. We calculated adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) for risk factors associated with oral HPV among participants not previously vaccinated.
Oral HPV was detected in 87 (9.4%) of 922; 9-valent vaccine types were detected in 37 (4.0%) of 922. Among HIV-positive participants, 17 (19.3%) of 88 had oral HPV detected. Oral HPV was more prevalent among those reporting first sex at 18 years of age or younger (aPR, 2.44; 95% CI, 1.16-5.12); HIV infection (aPR, 1.99; 95% CI, 1.14-3.48); greater than 5 sex partners within the past month (aPR, 1.93; 95% CI, 1.13-3.31); performing oral sex on greater than 5 partners within the last 3 months (aPR, 1.87; 95% CI, 1.12-3.13); and having greater than 5 male sex partners within the last 3 months (aPR, 1.76; 95% CI, 1.08-2.87). Only 454 (49.2%) of 922 were aware that HPV can cause oropharyngeal cancers.
Many oral HPV infections were with types targeted by vaccination. Oral HPV infections were significantly associated with HIV and sexual behaviors. Fewer than half of participants were aware that HPV could cause oropharyngeal cancer.
男男性行为者（MSM）面临着 HPV 导致的癌症风险，包括口咽癌。美国建议对 MSM 进行 HPV 疫苗接种，接种年龄截至 26 岁。口腔 HPV 感染与口咽癌有关。我们确定了年轻 MSM 中口腔 HPV 的流行率和危险因素。
青年男性 HPV 研究在 2012 年至 2014 年期间，从芝加哥和洛杉矶的诊所招募了年龄在 18 至 26 岁的 MSM。参与者自我报告人口统计学、性行为、疫苗接种和人类免疫缺陷病毒（HIV）状况。通过 L1-一致聚合酶链反应（PCR）对自我采集的口腔冲洗标本进行 HPV DNA（37 种类型）检测。我们计算了在未接种疫苗的参与者中，与口腔 HPV 相关的危险因素的调整后患病率比（aPR）和 95%置信区间（CI）。
在 922 名参与者中，有 87 名（9.4%）检测到口腔 HPV；9 价疫苗类型在 922 名参与者中检出 37 例（4.0%）。在 HIV 阳性参与者中，88 名中有 17 名（19.3%）检测到口腔 HPV。在报告 18 岁或以下首次性行为的参与者中，口腔 HPV 的流行率更高（aPR，2.44；95%CI，1.16-5.12）；HIV 感染（aPR，1.99；95%CI，1.14-3.48）；过去一个月有超过 5 个性伴侣（aPR，1.93；95%CI，1.13-3.31）；在过去 3 个月内对超过 5 个性伴侣进行口交（aPR，1.87；95%CI，1.12-3.13）；过去 3 个月内有超过 5 个男性性伴侣（aPR，1.76；95%CI，1.08-2.87）。在 922 名参与者中，只有 454 名（49.2%）知道 HPV 可导致口咽癌。
许多口腔 HPV 感染与疫苗接种所针对的类型有关。口腔 HPV 感染与 HIV 和性行为显著相关。不到一半的参与者知道 HPV 可导致口咽癌。
