Calò L, Cantaro S, Vianello A, Vido L, Rizzoni G, Borsatti A
Prostaglandins. 1986 Jul;32(1):116-20. doi: 10.1016/0090-6980(86)90152-8.
Blood concentration of PGE2, F2a, 6 keto PGF1a (6kF1a), TxB2 and 13, 14 dehydro 15 keto PGE2 (13, 14 OH 15 k E2) were measured in renal artery and vein of a patient with a PGs producing nephroblastoma. The tumor tissue produced PGs in the following order: PGF2a greater than PGE2 greater than TxB2 greater than 6kF1a greater than 13, 14 OH 15 k E2. However, renal artery concentration of the substances were as follows: 13, 14 OH 15 k E2 greater than TxB2 greater than 6kF1a greater than PGF2a greater than PGE2. Since arterial concentration is critical to postulating a calcium mobilizing effect on bone tissue, PGE2 arterial level seems to be too low to exert a pathogenetic role on hypercalcemia, at least in the patient reported here.
对一名患有产生前列腺素的肾母细胞瘤患者的肾动脉和肾静脉中的前列腺素E2（PGE2）、前列腺素F2α（F2α）、6-酮-前列腺素F1α（6kF1α）、血栓素B2（TxB2）和13,14-脱氢-15-酮-前列腺素E2（13,14-OH-15-k E2）的血药浓度进行了测量。肿瘤组织产生前列腺素的顺序如下：前列腺素F2α＞前列腺素E2＞血栓素B2＞6-酮-前列腺素F1α＞13,14-OH-15-k E2。然而，这些物质在肾动脉中的浓度如下：13,14-OH-15-k E2＞血栓素B2＞6-酮-前列腺素F1α＞前列腺素F2α＞前列腺素E2。由于动脉浓度对于假定对骨组织的钙动员作用至关重要，前列腺素E2的动脉水平似乎过低，至少在此处报道的患者中，无法对高钙血症发挥致病作用。
