Najar Mehdi, Fayyad-Kazan Mohammad, Merimi Makram, Burny Arsène, Bron Dominique, Fayyad-Kazan Hussein, Meuleman Nathalie, Lagneaux Laurence
Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC, Canada.
Laboratory of Physiology, Ethnopharmacology and Genetics, Faculty of Sciences, University Mohammed Premier, Oujda, Morocco.
Curr Stem Cell Res Ther. 2019;14(1):14-21. doi: 10.2174/1574888X13666180912125736.
Mesenchymal stromal cells (MSCs), characterized by both multidifferentiation potential and potent immunomodulatory capacity, represent a promising, safe and powerful cell based-therapy for repairing tissue damage and/or treating diseases associated with aberrant immune responses. Natural killer (NK) cells are granular lymphocytes of the innate immune system that function alone or in combination with other immune cells to combat both tumors and virally infected cells. After their infusion, MSCs are guided by host inflammatory elements and can interact with different immune cells, particularly those of the innate immune system. Although some breakthroughs have been achieved in understanding these interactions, much remains to be determined. In this review, we discuss the complex interactions between NK cells and MSCs, particularly the importance of improving the therapeutic value of MSCs.
间充质基质细胞（MSCs）具有多向分化潜能和强大的免疫调节能力，是一种很有前景的、安全且有效的基于细胞的疗法，可用于修复组织损伤和/或治疗与异常免疫反应相关的疾病。自然杀伤（NK）细胞是先天免疫系统的颗粒淋巴细胞，可单独发挥作用或与其他免疫细胞联合作用，以对抗肿瘤细胞和病毒感染细胞。输注后，MSCs受宿主炎症因子引导，并可与不同免疫细胞相互作用，尤其是先天免疫系统的免疫细胞。尽管在理解这些相互作用方面已取得一些突破，但仍有许多有待确定。在本综述中，我们讨论了NK细胞与MSCs之间的复杂相互作用，特别是提高MSCs治疗价值的重要性。
