Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows.

The aim of the present study was to investigate the bioavailability of quercetin from onion bulb (OB) and onion skin (OS) extracts in ruminants. Three non-lactating cows equipped with a permanent rumen fistula intraruminally received equimolar amounts of quercetin as either aglycone, rutin, or OB or OS extract, respectively, at a dose of 50 mg of quercetin equivalents/kg of body weight. Blood samples were drawn before and frequently within the 24 h period after application of the respective substance. Quercetin and quercetin metabolites with an intact flavonol structure (kaempferol, isorhamnetin, and tamarixetin) were analyzed in plasma samples by high-performance liquid chromatography with fluorescence detection. All quercetin sources administered resulted in a fast increase of the plasma concentrations of quercetin and total flavonols (sum of quercetin and its metabolites), followed by a rapid decline, whereby significant higher concentrations occurred with OB extract and rutin compared to quercetin aglycone and OS extract, respectively. The results clearly demonstrate a higher systemic availability of quercetin from OB extract and rutin. Taken together, OB extract with a high content of quercetin glucosides is an interesting source for the application of quercetin to ruminants.