Flatt P R, Bailey C J, Swanston-Flatt S K
Acta Endocrinol (Copenh). 1986 Sep;113(1):82-7. doi: 10.1530/acta.0.1130082.
The growth and metabolic effects of a transplantable radiation-induced rat insulinoma were examined in intact male and female New England Deaconess Hospital (NEDH) rats, and in parathyroidectomised or adrenalectomised male NEDH rats. Subscapular transplantation of insulinoma fragments in intact male rats consistently produced a highly vascularised encapsulated tumour associated with hyperphagia, hyperinsulinaemia and hypoglycaemia which progressed to fatal neuroglycopaenic coma by 30 +/- 0.8 days (mean +/- SEM) and 19 +/- 0.5 days for slow-growing and fast-growing tumour sublines respectively (P less than 0.001). In intact female rats transplanted with the slow-growing subline, the onset of hyperphagia was advanced by 4 days and the severity of hyperinsulinaemia and hypoglycaemia increased (21% and 36%; P less than 0.01 and P less than 0.001, respectively), resulting in a 10% decrease of survival time (P less than 0.05) and a 65% reduction of tumour weight (P less than 0.01). Transplantation of the fast-growing subline into parathyroidectomised male rats, which exhibited a 15-24% (P less than 0.05 - less than 0.01) decrease of plasma calcium, did not modify either the growth or metabolic effects of the tumour. In contrast, transplantation of this subline into adrenalectomised male rats decreased survival time by 32% (P less than 0.001) and reduced final tumour weight by 88% (P less than 0.02) without markedly affecting the onset or magnitude of the hyperinsulinaemia. These results indicate that the growth and metabolic effects of the transplantable NEDH rat insulinoma are modified by the presence of ovarian hormones and by adrenal hormones.(ABSTRACT TRUNCATED AT 250 WORDS)
在完整的雄性和雌性新英格兰女执事医院（NEDH）大鼠以及甲状旁腺切除或肾上腺切除的雄性NEDH大鼠中，研究了可移植的辐射诱导大鼠胰岛素瘤的生长和代谢效应。在完整的雄性大鼠中，肩胛下移植胰岛素瘤碎片始终会产生一个高度血管化的包膜肿瘤，伴有食欲亢进、高胰岛素血症和低血糖症，生长缓慢和快速生长的肿瘤亚系分别在30±0.8天（平均值±标准误）和19±0.5天发展为致命的神经低血糖昏迷（P<0.001）。在移植了生长缓慢亚系的完整雌性大鼠中，食欲亢进的发作提前了4天，高胰岛素血症和低血糖症的严重程度增加（分别为21%和36%；P<0.01和P<0.001），导致存活时间减少10%（P<0.05），肿瘤重量减少65%（P<0.01）。将快速生长亚系移植到甲状旁腺切除的雄性大鼠中，其血浆钙降低了15 - 24%（P<0.05 - <0.01），但并未改变肿瘤的生长或代谢效应。相比之下，将该亚系移植到肾上腺切除的雄性大鼠中，存活时间减少了32%（P<0.001），最终肿瘤重量减少了88%（P<0.02），而对高胰岛素血症的发作或程度没有明显影响。这些结果表明，可移植的NEDH大鼠胰岛素瘤 的生长和代谢效应受到卵巢激素和肾上腺激素的影响。（摘要截断于250字）
