透明细胞肉瘤——综述
Clear cell sarcoma-A review.
作者信息
Ibrahim Rami Mossad, Steenstrup Jensen Signe, Juel Jacob
机构信息
Department Plastic and Reconstructive Surgery, Herlev Hospital, Copenhagen, Denmark.
Department of Plastic and Reconstructive Surgery, Odense University Hospital, Odense, Denmark.
出版信息
J Orthop. 2018 Sep 6;15(4):963-966. doi: 10.1016/j.jor.2018.08.039. eCollection 2018 Dec.
Abstract
Clear cell sarcoma (CCS) previously known as malignant melanoma (MM) of the soft tissue, although, similar in morphology to MM, contemporary histopathologic and cytogenetic techniques have made this diagnosis obsolete, as it is now possible to distinguish between CCS and MM. CCS is often diagnosed in young adults with median age of 25 years. Overall mortality is generally poor, and the 5-year survival is between 40 and 60%. Hence, early diagnosis and radical surgery are key in the treatment of this extremely rare malignancy of the soft tissue comprising only about 1% of all sarcomas. This article present an overview of this rare malignancy.
摘要
透明细胞肉瘤（CCS）以前被称为软组织恶性黑色素瘤（MM），尽管其形态与MM相似，但现代组织病理学和细胞遗传学技术已使这种诊断过时，因为现在可以区分CCS和MM。CCS常发生于年轻成年人，中位年龄为25岁。总体死亡率通常较高，5年生存率在40%至60%之间。因此，早期诊断和根治性手术是治疗这种极为罕见的软组织恶性肿瘤的关键，该肿瘤仅占所有肉瘤的约1%。本文概述了这种罕见的恶性肿瘤。
相似文献
1
Clear cell sarcoma-A review.透明细胞肉瘤——综述
J Orthop. 2018 Sep 6;15(4):963-966. doi: 10.1016/j.jor.2018.08.039. eCollection 2018 Dec.
2
A case of clear cell sarcoma-A rare malignancy.一例透明细胞肉瘤——一种罕见的恶性肿瘤。
Int J Surg Case Rep. 2017;36:151-154. doi: 10.1016/j.ijscr.2017.05.034. Epub 2017 Jun 1.
3
Superficial Clear Cell Sarcoma (Melanoma of Soft Parts) of the Large toe in an 80-Year-Old Female With a Rare Cytogenetic Translocation.一名80岁女性大脚趾的浅表性透明细胞肉瘤（软组织黑色素瘤）伴罕见细胞遗传学易位
Cureus. 2020 Nov 26;12(11):e11719. doi: 10.7759/cureus.11719.
4
Intestinal Clear Cell Sarcoma-A Case Presentation of an Extremely Rare Tumor and Literature Review.肠透明细胞肉瘤——一种极其罕见肿瘤的病例报告及文献复习。
Medicina (Kaunas). 2024 May 22;60(6):847. doi: 10.3390/medicina60060847.
5
Clear cell sarcoma of soft tissue: a retrospective review and analysis of 31 cases treated at Istituto Ortopedico Rizzoli.软组织透明细胞肉瘤：Istituto Ortopedico Rizzoli 治疗的 31 例回顾性分析。
Eur J Surg Oncol. 2014 May;40(5):505-510. doi: 10.1016/j.ejso.2014.01.016. Epub 2014 Feb 2.
6
Clear-Cell Sarcoma With an Unusual Presentation Mimicking Metastatic Melanoma.表现不寻常、酷似转移性黑色素瘤的透明细胞肉瘤
Cureus. 2022 Nov 29;14(11):e32010. doi: 10.7759/cureus.32010. eCollection 2022 Nov.
7
Unusual Clinical Presentation of Clear Cell Sarcoma in a Young Woman.年轻女性中透明细胞肉瘤的不典型临床表现。
Oncology (Williston Park). 2023 Oct 10;37(10):412-416. doi: 10.46883/2023.25921005.
8
9
Clear cell sarcoma of soft tissue in pleural cavity: A case report.胸腔软组织透明细胞肉瘤：一例报告
World J Clin Cases. 2019 Oct 6;7(19):3126-3131. doi: 10.12998/wjcc.v7.i19.3126.
10
Clear cell sarcoma arising from paraspinal ligament of thoracic spine: Report of an unusual case.起源于胸椎椎旁韧带的透明细胞肉瘤：1例罕见病例报告
Indian J Pathol Microbiol. 2018 Apr-Jun;61(2):245-247. doi: 10.4103/IJPM.IJPM_516_17.
引用本文的文献
1
Clear Cell Sarcoma Incidence and Survival: A Surveillance, Epidemiology, and End Results (SEER) Database Analysis.透明细胞肉瘤的发病率与生存率：一项监测、流行病学及最终结果（SEER）数据库分析
Cureus. 2025 Jun 9;17(6):e85606. doi: 10.7759/cureus.85606. eCollection 2025 Jun.
2
Unleashing the future of cancer immunotherapy: in silico design of a multi-epitope and mRNA vaccine duo targeting EWSR1-ATF1, EWSR1-CREB1, and PRAME to conquer clear cell sarcoma using immunoinformatics approaches.释放癌症免疫治疗的未来：利用免疫信息学方法对靶向EWSR1-ATF1、EWSR1-CREB1和PRAME的多表位和mRNA疫苗组合进行计算机设计，以攻克透明细胞肉瘤。
Med Oncol. 2025 Jun 28;42(8):295. doi: 10.1007/s12032-025-02863-6.
3
Clinical characterization and therapeutic targeting of fusion genes in oncology.肿瘤学中融合基因的临床特征及治疗靶点
Future Oncol. 2025 Apr;21(10):1249-1260. doi: 10.1080/14796694.2025.2477974. Epub 2025 Mar 24.
4
Primary intraretinal clear cell sarcoma presenting as an amelanotic circumpapillary tumor.表现为无色素性视乳头周围肿瘤的原发性视网膜内透明细胞肉瘤。
Am J Ophthalmol Case Rep. 2025 Jan 17;37:102251. doi: 10.1016/j.ajoc.2025.102251. eCollection 2025 Mar.
5
Is Magnetic Resonance Imaging Able to Provide Specific Diagnoses? A Case Report of Clear Cell Sarcoma of Soft Tissue in the First Metacarpal of the Hand.磁共振成像能否提供特异性诊断？手部第一掌骨软组织透明细胞肉瘤病例报告。
Case Rep Oncol. 2024 Sep 9;17(1):995-1000. doi: 10.1159/000540745. eCollection 2024 Jan-Dec.
6
Medical imaging for the diagnosis, recurrence and metastasis evaluation of clear cell sarcoma.用于透明细胞肉瘤诊断、复发及转移评估的医学成像
World J Clin Cases. 2024 Oct 16;12(29):6258-6261. doi: 10.12998/wjcc.v12.i29.6258.
7
Essential role of postoperative follow-up in the management of clear cell sarcoma.术后随访在透明细胞肉瘤管理中的重要作用。
World J Clin Cases. 2024 Aug 16;12(23):5299-5303. doi: 10.12998/wjcc.v12.i23.5299.
8
Biological and therapeutic insights from animal modeling of fusion-driven pediatric soft tissue sarcomas.融合驱动型儿科软组织肉瘤动物模型的生物学和治疗学见解。
Dis Model Mech. 2024 Jun 1;17(6). doi: 10.1242/dmm.050704. Epub 2024 Jun 25.
9
Navigating diagnostic challenges-distinguishing malignant melanoma and clear cell sarcoma of soft tissues: a case report and review of the literature.诊断挑战：恶性黑色素瘤与软组织透明细胞肉瘤的鉴别——病例报告及文献复习
J Med Case Rep. 2024 May 17;18(1):249. doi: 10.1186/s13256-024-04542-y.
10
A Comparison of Clear Cell Sarcoma to Jaw and Salivary Tumors Bearing EWS Fusions.透明细胞肉瘤与具有 EWS 融合的颌骨和唾液腺肿瘤的比较。
Head Neck Pathol. 2024 Mar 25;18(1):25. doi: 10.1007/s12105-024-01625-6.
本文引用的文献
1
Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.软组织和内脏肉瘤：ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2014 Sep;25 Suppl 3:iii102-12. doi: 10.1093/annonc/mdu254.
2
Absence of 19 known hotspot oncogenic mutations in soft tissue clear cell sarcoma: two cases report with review of the literature.软组织透明细胞肉瘤中19种已知热点致癌突变的缺失：两例报告并文献复习
Int J Clin Exp Pathol. 2014 Jul 15;7(8):5242-9. eCollection 2014.
3
Follow-up in soft tissue sarcomas.软组织肉瘤的随访
Memo. 2014;7(2):92-96. doi: 10.1007/s12254-014-0146-8. Epub 2014 Jun 13.
4
Clear cell sarcoma of tendons and aponeuroses, and osteoclast-rich tumour of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: a review and update.腱膜和肌腱的透明细胞肉瘤，以及具有类似于软组织透明细胞肉瘤特征的富含破骨细胞的胃肠道肿瘤：综述和更新。
J Clin Pathol. 2010 May;63(5):416-23. doi: 10.1136/jcp.2008.057471.
5
Chemotherapy in clear cell sarcoma.透明细胞肉瘤的化疗。
Med Oncol. 2011 Sep;28(3):859-63. doi: 10.1007/s12032-010-9502-7.
6
A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma.局部可切除软组织肉瘤术前与术后放疗的肿瘤学结局的系统评价和荟萃分析。
Ann Surg Oncol. 2010 May;17(5):1367-74. doi: 10.1245/s10434-009-0885-7. Epub 2010 Mar 9.
7
Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts).透明细胞肉瘤（软组织黑色素瘤）中EWSR1/ATF1和EWSR1/CREB1嵌合转录本的检测与特征分析。
Mod Pathol. 2009 Sep;22(9):1201-9. doi: 10.1038/modpathol.2009.85. Epub 2009 Jun 26.
8
Clear cell sarcoma of the temporal region: case report, review of the literature, and genetic analysis.颞区透明细胞肉瘤：病例报告、文献综述及基因分析
J Oral Maxillofac Surg. 2009 Apr;67(4):910-4. doi: 10.1016/j.joms.2008.06.092.
9
Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases.软组织透明细胞肉瘤：33例临床病理、免疫组化及分子分析
Am J Surg Pathol. 2008 Mar;32(3):452-60. doi: 10.1097/PAS.0b013e31814b18fb.
10
Clear cell sarcoma of tendons and aponeuroses: a review.肌腱和腱膜透明细胞肉瘤：综述
Arch Pathol Lab Med. 2007 Jan;131(1):152-6. doi: 10.5858/2007-131-152-CCSOTA.
Zotero 插件