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胫骨成釉细胞瘤:单一机构连续7例病例分析

TIBIAL ADAMANTINOMA: ANALYSIS OF SEVEN CONSECUTIVE CASES IN A SINGLE INSTITUTION.

作者信息

Zumárraga Juan Pablo, Cartolano Ricardo, Kohara Marcelo Tomio, Baptista André Mathias, Dos Santos Felipe Gonçalves, de Camargo Olavo Pires

机构信息

Orthopedic Oncology Group, Instituto de Ortopedia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Instituto de Ortopedia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

出版信息

Acta Ortop Bras. 2018;26(4):252-254. doi: 10.1590/1413-785220182604192680.

Abstract

OBJECTIVE

Adamantinoma accounts for less than 1% of the primary bone neoplasms. The tibia is the most affected bone and it is predominant in male patients between the second and third decades of life. The objective of this study is to obtain epidemiological and clinical information on patients with adamantinoma of the tibia treated surgically between 1989 and 2016.

METHODS

Retrospective series of seven patients diagnosed with adamantinoma of the tibia that underwent surgery at the orthopedic oncology service of our hospital. The information was obtained from the medical records and histopathological reports of our institution.

RESULTS

A total of 2870 medical records with histological reports were evaluated. Seven cases of adamantinoma of the tibia were included. The mean age was 28.5 (17-49) years. We found a predominance of females (71.4%) and the most affected side was the left one, with four cases (57.1%). The biopsy revealed bone adamantinoma in four (57.1%) patients, while the diagnosis of the other patients was confirmed after the histological examination of the surgical specimen. All the patients underwent surgery as definitive treatment. No positive margins were reported. No local recurrence (LR) was reported and two patients had distant metastasis (DM).

CONCLUSION

The prognosis of survival in cases of adamantinoma of the tibia is high. The rates of LR and DM were low. Surgical treatment with extensive tumor resection is the treatment of choice.

摘要

目的

骨釉质细胞瘤占原发性骨肿瘤的比例不到1%。胫骨是最常受累的骨骼,主要发生于20至30岁的男性患者。本研究的目的是获取1989年至2016年间接受手术治疗的胫骨骨釉质细胞瘤患者的流行病学和临床信息。

方法

回顾性研究我院骨科肿瘤服务中心诊断为胫骨骨釉质细胞瘤并接受手术的7例患者。信息来自我们机构的病历和组织病理学报告。

结果

共评估了2870份有组织学报告的病历。纳入7例胫骨骨釉质细胞瘤病例。平均年龄为28.5岁(17至49岁)。我们发现女性占优势(71.4%),最常受累的一侧是左侧,有4例(57.1%)。活检显示4例(57.1%)患者为骨釉质细胞瘤,而其他患者的诊断在手术标本的组织学检查后得到证实。所有患者均接受手术作为确定性治疗。未报告切缘阳性。未报告局部复发(LR),2例患者发生远处转移(DM)。

结论

胫骨骨釉质细胞瘤的生存预后良好。LR和DM的发生率较低。广泛肿瘤切除的手术治疗是首选治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6eb/6131285/3ed01bb2cbb1/1809-4406-aob-26-04-0252-gf01.jpg

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