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一位黄皮肤厨师的复杂病例:孤立性高胆红素血症

The Spiraling Case of a Yellow Chef: Isolated Hyperbilirubinemia.

作者信息

Jiang Karen, Bazarbashi Ahmad Najdat, Dahdal Sami, Voiculescu Adina, Khalaf Natalia

机构信息

Division of Hospital Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.

出版信息

Case Reports Hepatol. 2018 Aug 23;2018:5876718. doi: 10.1155/2018/5876718. eCollection 2018.

DOI:10.1155/2018/5876718
PMID:30210882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6126086/
Abstract

Leptospirosis is a common bacterial disease in tropical regions of the world due to greater exposure to rodents and domestic animals; however, this condition can also occur in US urban areas, though it often goes unrecognized. Gastrointestinal symptoms are very commonly seen, and icteric leptospirosis is often confused for other conditions resulting in delayed diagnosis and worse outcomes. As mortality increases with more extensive hepatic involvement, gastroenterologists should be aware of the constellation of gastrointestinal symptoms related to leptospirosis, as it can occur in the absence of classic exposure history.

摘要

钩端螺旋体病是一种在世界热带地区常见的细菌性疾病,因为人们更多地接触啮齿动物和家畜;然而,这种疾病在美国城市地区也可能发生,尽管它常常未被识别。胃肠道症状非常常见,黄疸型钩端螺旋体病常被误诊为其他疾病,导致诊断延迟和预后更差。由于随着肝脏受累范围扩大死亡率会增加,胃肠病学家应了解与钩端螺旋体病相关的一系列胃肠道症状,因为在没有典型暴露史的情况下也可能发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c9e/6126086/6c96eff7a78f/CRIHEP2018-5876718.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c9e/6126086/6c96eff7a78f/CRIHEP2018-5876718.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c9e/6126086/6c96eff7a78f/CRIHEP2018-5876718.001.jpg

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本文引用的文献

1
A Systematic Review of the Mortality from Untreated Leptospirosis.未经治疗的钩端螺旋体病死亡率的系统评价
PLoS Negl Trop Dis. 2015 Jun 25;9(6):e0003866. doi: 10.1371/journal.pntd.0003866. eCollection 2015.
2
Leptospirosis in humans.人类中的钩端螺旋体病。
Curr Top Microbiol Immunol. 2015;387:65-97. doi: 10.1007/978-3-662-45059-8_5.
3
Destruction of the hepatocyte junction by intercellular invasion of Leptospira causes jaundice in a hamster model of Weil's disease.细胞间侵袭导致裂体吸虫破坏肝细胞连接,从而引起威氏病仓鼠模型的黄疸。
Cureus. 2021 Apr 1;13(4):e14241. doi: 10.7759/cureus.14241.
Int J Exp Pathol. 2014 Aug;95(4):271-81. doi: 10.1111/iep.12085. Epub 2014 Jun 19.
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Antibiotics for leptospirosis.用于治疗钩端螺旋体病的抗生素。
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Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world.新发、控制和再发钩端螺旋体病:变化世界中的感染动态。
Clin Microbiol Infect. 2011 Apr;17(4):494-501. doi: 10.1111/j.1469-0691.2011.03474.x.
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Leptospirosis: an emerging global public health problem.钩端螺旋体病:一个新出现的全球公共卫生问题。
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Clinical characteristics and risk factors of human leptospirosis in Argentina (1999-2005).阿根廷人钩端螺旋体病的临床特征及危险因素(1999 - 2005年)
Acta Trop. 2008 Sep;107(3):255-8. doi: 10.1016/j.actatropica.2008.06.007. Epub 2008 Jul 12.
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Assessment of the clinical presentation and treatment of 353 cases of laboratory-confirmed leptospirosis in Hawaii, 1974-1998.1974年至1998年夏威夷353例实验室确诊钩端螺旋体病的临床表现及治疗评估
Clin Infect Dis. 2001 Dec 1;33(11):1834-41. doi: 10.1086/324084. Epub 2001 Oct 23.
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Leptospirosis.钩端螺旋体病
Clin Microbiol Rev. 2001 Apr;14(2):296-326. doi: 10.1128/CMR.14.2.296-326.2001.
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Sporadic urban leptospirosis.散发性城市钩端螺旋体病
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