血管加压素控制静脉曲张出血：一项前瞻性随机研究。
Control of bleeding varices by vasopressin: a prospective randomized study.
作者信息
Johnson W C, Widrich W C, Ansell J E, Robbins A H, Nabseth D C
出版信息
Ann Surg. 1977 Sep;186(3):369-76. doi: 10.1097/00000658-197709000-00015.
Abstract
From July 1975 to November 1976 25 patients with bleeding esophagogastric varices documented by endoscopy who failed to respond to conservative medical treatment were transferred to the Surgical Service. These patients, who were mainly Child's Class "C" alcoholic cirrhotic patients, were treated with vasopressin infused continuously using a standardized dose into either a peripheral vein or the superior mesenteric artery (SMA) according to a predetermined randomization. No significant difference in efficacy for control of bleeding (average rate = 56%) related to route of administration was found. Because catheter-related complications in the SMA group were significantly greater, we concluded that the method of choice in vasopressin treatment of esophagogastric variceal bleeding is a continuous infusion by way of a peripheral vein.
摘要
1975年7月至1976年11月，25例经内镜检查证实有食管胃静脉曲张出血且对保守药物治疗无效的患者转入外科治疗。这些患者主要是Child's C级酒精性肝硬化患者，根据预先确定的随机分组，采用标准化剂量的血管加压素持续输注，经外周静脉或肠系膜上动脉（SMA）给药。结果发现，与给药途径相关的出血控制效果（平均成功率 = 56%）无显著差异。由于SMA组与导管相关的并发症明显更多，我们得出结论，血管加压素治疗食管胃静脉曲张出血的首选方法是经外周静脉持续输注。
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