Stewart Holly L, Kawcak Christopher E
Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Front Vet Sci. 2018 Aug 28;5:178. doi: 10.3389/fvets.2018.00178. eCollection 2018.
Subchondral bone plays a critical role in the pathogenesis of osteochondral disease across veterinary species. The subchondral bone is highly adaptable, with the ability to model and remodel in response to loading stresses experienced by the joint. Repetitive stress injuries within the joint can result in primary or secondary pathologic lesions within the subchondral bone, which have been recognized to contribute to the development and progression of osteoarthritis. Recent advances in diagnostic imaging, particularly volumetric imaging modalities have facilitated earlier identification of subchondral bone disease. Despite these advancements, limitations in our knowledge about subchondral bone makes treatment and prevention of these conditions challenging. The purpose of this report is to review our current understanding of subchondral bone and its relationship to osteoarthritis across veterinary species, with a specific focus in the research that has been performed in horses. It can be concluded that our current understanding of subchondral bone is advancing, and future experimental, clinical and pathologic studies will provide additional insight about subchondral bone and its relationship to joint disease.
在所有兽医物种中，软骨下骨在骨软骨疾病的发病机制中起着关键作用。软骨下骨具有高度适应性，能够根据关节所承受的负荷应力进行塑形和重塑。关节内的重复性应力损伤可导致软骨下骨出现原发性或继发性病理病变，这些病变被认为会促进骨关节炎的发展和进展。诊断成像技术的最新进展，尤其是容积成像方式，有助于更早地识别软骨下骨疾病。尽管有这些进展，但我们对软骨下骨的认识存在局限性，这使得这些疾病的治疗和预防具有挑战性。本报告的目的是回顾我们目前对软骨下骨及其与所有兽医物种骨关节炎关系的理解，特别关注在马匹中进行的研究。可以得出结论，我们目前对软骨下骨的理解正在不断进步，未来的实验、临床和病理研究将为软骨下骨及其与关节疾病的关系提供更多见解。
