Louie G L, Prokocimer P G, Nicholls E A, Maze M
Brain Res. 1986 Sep 24;383(1-2):377-81. doi: 10.1016/0006-8993(86)90044-2.
We investigated the effect of aminophylline on thiopental sleep-times and monoamine neurotransmitter turnover rates in discrete brain areas. Aminophylline-treated rats had shorter thiopental sleep-times than saline-treated controls. Noradrenergic neurotransmission was greater following aminophylline treatment in thiopental-anesthetized rats in all brain areas while turnover in other monoaminergic pathways was unchanged. These data suggest that acute aminophylline treatment increases central noradrenergic neurotransmission which pharmacodynamically diminishes the hypnotic response to thiopental.
我们研究了氨茶碱对硫喷妥钠睡眠时间以及离散脑区单胺神经递质周转率的影响。与生理盐水处理的对照组相比，氨茶碱处理的大鼠硫喷妥钠睡眠时间更短。在硫喷妥钠麻醉的大鼠中，氨茶碱处理后所有脑区的去甲肾上腺素能神经传递增强，而其他单胺能途径的周转率未发生变化。这些数据表明，急性氨茶碱处理可增加中枢去甲肾上腺素能神经传递，这在药效学上减弱了对硫喷妥钠的催眠反应。
