Cardinali D P
Eur J Pharmacol. 1978 Jan 15;47(2):239-43. doi: 10.1016/0014-2999(78)90397-7.
In the brain of rats injected with pentoxifylline [3,7-dimethyl-1(5-oxo-hexyl)-xanthine] or aminophylline the following was observed: (i) dose-dependent increases of tryptophan and 5-hydroxyindoleacetic acid levels and of 5-hydroxytryptophan and dihydroxyphenylalanine accumulation after treatment with the decarboxylase inhibitor benserazide HCl; (ii) acceleration of norepinephrine turnover following alpha-methyl-p-tyrosine; (iii) increase of 3-methoxytyramine accumulation following pargyline. On a molar basis pentoxifylline was more potent than aminophylline in affecting brain biogenic amine metabolism.
在注射己酮可可碱[3,7-二甲基-1-(5-氧代己基)-黄嘌呤]或氨茶碱的大鼠脑中观察到以下情况：(i) 在用盐酸苄丝肼治疗后，色氨酸和5-羟吲哚乙酸水平以及5-羟色氨酸和二羟基苯丙氨酸积累呈剂量依赖性增加；(ii) 在使用α-甲基-p-酪氨酸后去甲肾上腺素周转加速；(iii) 在使用帕吉林后3-甲氧基酪胺积累增加。在摩尔基础上，己酮可可碱在影响脑生物胺代谢方面比氨茶碱更有效。
