Wang Ping, Zhang Ying-Jian, Li Yi-Ran, Liu Xiao-Min, Lv Shu-Yan, Xia Xiao-Yan
Department of Preventive Medicine, Henan University of Science and Technology Department of Gastroenterology, First Affiliated Hospital Henan University of Science and Technology, Luoyang, China.
Medicine (Baltimore). 2018 Sep;97(37):e12070. doi: 10.1097/MD.0000000000012070.
This study aims to investigate the relationship between gastrointestinal dysfunction (GD) and cirrhosis severity in cirrhotic patients, to provide evidences for the prevention and treatment of GD in cirrhotic patients.A total of 95 cirrhotic inpatients and outpatients, who were treated in the Department of Gastroenterology of Xinqu Hospital of the First Affiliated Hospital of Henan University of Science and Technology, were enrolled in the present study, and assigned as the experimental group (cirrhosis group). According to Child-Pugh classification, these patients were divided into 3 groups: group A (n = 45), group B (n = 23), and group C (n = 27). Forty healthy adults who received health check-ups during the same period served as the control group. The gastrointestinal (GI) symptoms of cirrhotic patients were scored, and the fasting serum gastrin (GAS), motilin (MTL), and vasoactive intestinal peptide (VIP) levels were measured in all subjects.The potential correlations of GI symptom scores of patients in these cirrhosis groups with GI hormone levels and cirrhosis severity were analyzed. In cirrhotic patients, the GI symptom scores significantly increased. Furthermore, the symptom scores gradually increased along with the aggravation of liver damage. Moreover, serum GAS and VIP levels were significantly higher in the cirrhosis groups than in the control group, whereas MTL levels were significantly lower. These changes were significantly correlated with cirrhosis severity. The linear correlation analysis revealed that the GI symptom score was positively correlated with GAS and VIP levels, and negatively correlated with MTL level. In addition, the linear correlation analysis revealed that GI symptom score and GAS and VIP levels were positively correlated with cirrhosis severity, whereas MTL level was negatively correlated with cirrhosis severity.Cirrhotic patients have more obvious GI symptoms and higher GI hormone levels, which are closely correlated with the progression of liver cirrhosis and the degree of liver function damage.
本研究旨在探讨肝硬化患者胃肠功能障碍（GD）与肝硬化严重程度之间的关系，为肝硬化患者GD的防治提供依据。选取河南科技大学第一附属医院新区医院消化内科收治的95例肝硬化住院及门诊患者作为本研究对象，设为实验组（肝硬化组）。根据Child-Pugh分级，将这些患者分为3组：A组（n = 45）、B组（n = 23）和C组（n = 27）。选取同期进行健康体检的40例健康成年人作为对照组。对肝硬化患者的胃肠道（GI）症状进行评分，并检测所有受试者空腹血清胃泌素（GAS）、胃动素（MTL）和血管活性肠肽（VIP）水平。分析这些肝硬化组患者的GI症状评分与GI激素水平及肝硬化严重程度之间的潜在相关性。肝硬化患者的GI症状评分显著升高。此外，症状评分随肝损伤加重而逐渐升高。而且，肝硬化组血清GAS和VIP水平显著高于对照组，而MTL水平显著低于对照组。这些变化与肝硬化严重程度显著相关。线性相关分析显示，GI症状评分与GAS和VIP水平呈正相关，与MTL水平呈负相关。此外，线性相关分析显示，GI症状评分以及GAS和VIP水平与肝硬化严重程度呈正相关，而MTL水平与肝硬化严重程度呈负相关。肝硬化患者有更明显的GI症状和更高的GI激素水平，这与肝硬化进展及肝功能损害程度密切相关。
