Lothe L, Ivarsson S A, Lindberg T
Acta Paediatr Scand. 1987 Mar;76(2):316-20. doi: 10.1111/j.1651-2227.1987.tb10467.x.
Intestinal hyperperistalsis is one part of the clinical picture in infantile colic. Three gut hormones involved in the regulation of gut motility; motilin, vasoactive intestinal peptide (VIP) and gastrin, were measured with the RIA method in: 40 infants with infantile colic, (age 2-22 weeks), 42 healthy age-matched infants, 11 children (age 3-36 months) with gastrointestinal disorders, and 20 children (age 3-36 months) with non-gastrointestinal disorder. Basal s-motilin levels were raised in infants with infantile colic (p less than 0.01) and in children with other gastrointestinal disorders (p less than 0.001). Formula-fed infants had higher basal s-motilin levels than the breast-fed infants (p less than 0.05). P-VIP and s-gastrin levels were raised in children with other gastro-intestinal disorders (p less than 0.05), but not in infantile colic. Formula-fed colicky infants had higher s-gastrin levels than the breast-fed colicky infants (p less than 0.05). We suggest that the increased s-motilin level in infantile colic might account in part for the clinical picture of this disorder.
肠道蠕动亢进是婴儿腹绞痛临床表现的一部分。采用放射免疫分析法测定了参与肠道运动调节的三种肠道激素：胃动素、血管活性肠肽（VIP）和胃泌素，检测对象包括：40例患有婴儿腹绞痛的婴儿（年龄2 - 22周）、42例年龄匹配的健康婴儿、11例患有胃肠道疾病的儿童（年龄3 - 36个月）以及20例患有非胃肠道疾病的儿童（年龄3 - 36个月）。患有婴儿腹绞痛的婴儿（p < 0.01）以及患有其他胃肠道疾病的儿童（p < 0.001），其基础血清胃动素水平升高。人工喂养的婴儿基础血清胃动素水平高于母乳喂养的婴儿（p < 0.05）。患有其他胃肠道疾病的儿童，其血浆VIP和血清胃泌素水平升高（p < 0.05），但婴儿腹绞痛患儿未见升高。人工喂养的腹绞痛婴儿血清胃泌素水平高于母乳喂养的腹绞痛婴儿（p < 0.05）。我们认为，婴儿腹绞痛时血清胃动素水平升高可能部分解释了该疾病的临床表现。
