Zhou Yaqing, Wang Shenggang
Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University Nantong 226600, Jiangsu Province, China.
Department of Gastrointestinal and Anal Diseases Surgery, Affiliated Hospital of Weifang Medical University Weifang 261000, Shandong Province, China.
Am J Transl Res. 2021 Nov 15;13(11):12929-12938. eCollection 2021.
To explore the efficacy of Jianpiyangxue granules on gastrointestinal autonomic nerve dysfunction and their impact on adverse reactions.
From September 2016 to September 2020, 120 patients with gastrointestinal autonomic nerve dysfunction treated in our hospital were retrospectively selected and randomly assigned to a treatment group (TG) which was administered Jianpiyangxue granules prepared by our hospital and a control group (CG) which was administered routine Western medicine treatment (B vitamins + oryzanol). There were 60 patients in each group. The clinical efficacy and incidences of adverse effects were compared between the groups. The gastrointestinal hormone indexes, the inflammatory cytokines, and the immune indexes were analyzed before and after the therapy. The gastrin (GAS) and motilin (MTL) levels were measured using the motilin stimulating method, and the somatostatin (SS) levels were measured using ELISA for comparison. The autonomic nerve dysfunction symptoms were used for the evaluation. The degree of neurological functional defects scale (NIHSS) was used to assess the neurological functional defect levels. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores were used to assess the patients' psychological statuses.
After the therapy, the GAS, MTL, and SS expressions in the TG were remarkably higher than they were in the CG. The CRP and IL-6 expressions in the TG were significantly lower than they were in the CG. The TG had higher IgG, IgM, and IgA levels as compared with the CG, higher grade 0 and grade 1 scores on the gastrointestinal autonomic nerve dysfunction, but lower grade 2 and 3 scores were observed compared to the CG. Significantly lower NIHSS, SAS, and SDS scores were recorded in the TG compared with the CG. The TG yielded more promising outcomes in terms of the total effective rate and the incidences of adverse reactions than the CG.
Jianpiyangxue granules contribute to enhancing the clinical efficacy, reducing the incidence of adverse reactions, and improving the gastrin, somatostatin, and other indicators in treating gastrointestinal autonomic nerve dysfunction.
探讨健脾养血颗粒对胃肠自主神经功能障碍的疗效及其对不良反应的影响。
回顾性选取2016年9月至2020年9月在我院治疗的120例胃肠自主神经功能障碍患者，随机分为治疗组（TG）和对照组（CG）。治疗组服用我院制备的健脾养血颗粒，对照组采用常规西药治疗（B族维生素+谷维素）。每组60例。比较两组的临床疗效和不良反应发生率。分析治疗前后的胃肠激素指标、炎症细胞因子和免疫指标。采用胃动素刺激法测定胃泌素（GAS）和胃动素（MTL）水平，采用酶联免疫吸附测定法（ELISA）测定生长抑素（SS）水平并进行比较。采用自主神经功能障碍症状进行评估。采用美国国立卫生研究院卒中量表（NIHSS）评估神经功能缺损程度。采用焦虑自评量表（SAS）和抑郁自评量表（SDS）评分评估患者的心理状态。
治疗后，治疗组的GAS、MTL和SS表达显著高于对照组。治疗组的CRP和IL-6表达显著低于对照组。与对照组相比，治疗组的IgG、IgM和IgA水平更高，胃肠自主神经功能障碍0级和1级评分更高，但2级和3级评分更低。与对照组相比，治疗组的NIHSS、SAS和SDS评分显著更低。治疗组在总有效率和不良反应发生率方面比对照组取得了更理想的结果。
健脾养血颗粒有助于提高治疗胃肠自主神经功能障碍的临床疗效，降低不良反应发生率，并改善胃泌素、生长抑素等指标。
