Lee Donghyoun, Jung Kyung Uk, Kim Hyung Ook, Kim Hungdai, Chun Ho-Kyung
Department of Surgery, Jeju National University Hospital, Jeju National University School of Medicine, Jeju Self-governing Province Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Medicine (Baltimore). 2018 Sep;97(37):e12244. doi: 10.1097/MD.0000000000012244.
Although periodontal disease and gastrointestinal tract health are closely associated, few studies have investigated whether periodontitis is a risk factor for colorectal adenoma. The aim of this study was to investigate whether there is an association between periodontitis and the risk of colorectal adenoma in asymptomatic healthy people.From January 2013 to October 2015, we retrospectively enrolled 42,871 patients who underwent health screening at Kangbuk Samsung Hospital in South Korea. Demographic and clinical data were collected before colonoscopy. We calculated the odds ratio (OR) for adenoma in these patients.The median age was 39.3 ± 8.7 years and 70.4% of the patients were men; 32.5% had a body mass index (BMI) 25.0 kg/m. The frequency of adenoma was 12% (n = 5136). A higher risk of adenoma was associated with the following factors: BMI 25.0 kg/m (OR 1.51, 95% confidence interval [CI]: 1.42-1.61), current smoker (OR 1.51, 95% CI: 1.42-1.61), former smoker (OR 1.28, 95% CI: 1.19-1.37), periodontitis (OR 1.95, 95% CI: 1.82-2.0), moderate alcohol intake (OR 1.8, 95% CI: 1.69-1.93), and heavy alcohol intake (OR 2.67, 95% CI: 2.24-3.18).Being male or a former or current smoker, alcohol intake above the moderate level, and periodontitis increase the risk of colorectal adenoma. These findings suggest that controlling oral disease is important to the prevention and management of colorectal adenoma. The findings of this study could be applied to risk stratification and colorectal cancer prevention programs, including screening guidelines.
尽管牙周病与胃肠道健康密切相关，但很少有研究调查牙周炎是否为结直肠腺瘤的危险因素。本研究旨在调查无症状健康人群中牙周炎与结直肠腺瘤风险之间是否存在关联。2013年1月至2015年10月，我们回顾性纳入了42871例在韩国江北三星医院接受健康筛查的患者。在结肠镜检查前收集人口统计学和临床数据。我们计算了这些患者患腺瘤的比值比（OR）。中位年龄为39.3±8.7岁，70.4%的患者为男性；32.5%的患者体重指数（BMI）≥25.0kg/m²。腺瘤的发生率为12%（n = 5136）。腺瘤风险较高与以下因素相关：BMI≥25.0kg/m²（OR 1.51，95%置信区间[CI]：1.42 - 1.61）、当前吸烟者（OR 1.51，95%CI：1.42 - 1.61）、既往吸烟者（OR 1.28，95%CI：1.19 - 1.37）、牙周炎（OR 1.95，95%CI：1.82 - 2.0）、适度饮酒（OR 1.8，95%CI：1.69 - 1.93）和大量饮酒（OR 2.67，95%CI：2.24 - 3.18）。男性、既往或当前吸烟者、饮酒量高于适度水平以及牙周炎会增加患结直肠腺瘤的风险。这些发现表明，控制口腔疾病对于结直肠腺瘤的预防和管理很重要。本研究结果可应用于风险分层和结直肠癌预防项目，包括筛查指南。
