Kim Jeehyun, Oh Seung-Won, Kim Young-Sun, Kwon Hyuktae, Joh Hee-Kyung, Lee Ji-Eun, Park Danbee, Park Jae-Hong, Ko Ah-Ryoung, Kim Ye-Ji
Department of Family Medicine, Seoul National University Hospital, Seoul, Korea Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea Department of Medicine, Seoul National University College of Medicine; Department of Family Medicine, Seoul National University Health Service Center, Seoul, Korea.
Medicine (Baltimore). 2017 Jan;96(1):e5759. doi: 10.1097/MD.0000000000005759.
The incidence of colorectal cancer is rapidly increasing in South Korea. It is important to clarify the association between colorectal cancer and diet, being one of the main modifiable risk factors, as such studies in the Korean population are lacking.A cross-sectional study was performed using data from participants who had undergone a screening colonoscopy and a nutritional assessment during a routine health check-up from January 2008 to December 2011. Dietary intake data were derived from 1-day food records; colorectal adenoma was histopathologically confirmed by biopsy during colonoscopy. Eventually, 2604 participants were included in the analysis. The risk of colorectal adenoma by quintile of dietary fat intake was analyzed using logistic regression. Subgroup analyses by degree of risk and by location of colorectal adenoma were additionally performed.In men, total fat intake was not associated with risk of colorectal adenoma. However, risk of colorectal adenoma increased with higher saturated fatty acid (SFA) intake. The adjusted odds ratio in the highest quintile was 1.71 (95% confidence interval, 1.01-2.91) compared with that in the lowest quintile. There was no significant association between fat intake and risk of colorectal adenoma characterized by subsite. In female participants, total fat and specific fatty acid intake were not associated with risk of colorectal adenoma.These data support that high SFA intake is associated with risk of colorectal adenoma in Korean men.
韩国结直肠癌的发病率正在迅速上升。明确结直肠癌与饮食之间的关联非常重要，饮食是主要的可改变风险因素之一，但韩国人群中此类研究尚缺。本横断面研究采用了2008年1月至2011年12月期间在常规健康检查中接受过结肠镜筛查和营养评估的参与者的数据。饮食摄入数据来自1天的食物记录；结肠直肠腺瘤通过结肠镜检查期间的活检进行组织病理学确认。最终，2604名参与者纳入分析。使用逻辑回归分析饮食脂肪摄入量五分位数与结肠直肠腺瘤风险的关系。还按风险程度和结肠直肠腺瘤位置进行了亚组分析。在男性中，总脂肪摄入量与结肠直肠腺瘤风险无关。然而，结肠直肠腺瘤风险随饱和脂肪酸（SFA）摄入量增加而升高。最高五分位数的校正比值比为1.71（95%置信区间，1.01 - 2.91），与最低五分位数相比。脂肪摄入量与按亚部位分类的结肠直肠腺瘤风险之间无显著关联。在女性参与者中，总脂肪和特定脂肪酸摄入量与结肠直肠腺瘤风险无关。这些数据支持高SFA摄入量与韩国男性结肠直肠腺瘤风险相关。
