Montplaisir J, Godbout R, Poirier G, Bédard M A
Clin Neuropharmacol. 1986;9(5):456-63. doi: 10.1097/00002826-198610000-00006.
Seven patients suffering from restless legs syndrome (RLS) and periodic movements in sleep (PMS) were investigated before and after treatment with L-Dopa. The effect of treatment was evaluated by polysomnography, structured interviews, and daily questionnaires. Sleep organization and subjective complaints improved during treatment with 100 to 200 mg of L-Dopa. Polysomnographic recordings also revealed a significant decrease of periodic leg movements during the first third of the night and a rebound during the last third. These results and previous biochemical findings raise the hypothesis that RLS and PMS may both result from reduced dopaminergic activity in the CNS, perhaps resulting from decreased sensibility of postsynaptic receptors.
七名患有不宁腿综合征（RLS）和睡眠周期性肢体运动（PMS）的患者在接受左旋多巴治疗前后接受了调查。通过多导睡眠图、结构化访谈和每日问卷对治疗效果进行评估。使用100至200毫克左旋多巴治疗期间，睡眠结构和主观症状有所改善。多导睡眠图记录还显示，夜间前三分之一时段周期性腿部运动显著减少，而后三分之一时段出现反弹。这些结果以及先前的生化研究结果提出了一个假设，即RLS和PMS可能都是由中枢神经系统中多巴胺能活性降低所致，这可能是由于突触后受体敏感性降低引起的。
