Montplaisir J, Lorrain D, Godbout R
Centre d'étude du sommeil, Hôpital du Sacré-Coeur, Montréal, Qué., Canada.
Eur Neurol. 1991;31(1):41-3. doi: 10.1159/000116643.
We report here the possible effect of opiates on a patient exhibiting particularly severe restless legs syndrome (RLS) and periodic leg movements in sleep (PLMS). This patient was investigated in the sleep laboratory under three conditions, namely, unmedicated (baseline), medicated with codeine sulfate, and medicated with both codeine sulfate and pimozide. Codeine sulfate dramatically improved abnormal motor behavior in this patient. The addition of pimozide reversed the beneficial effect of codeine during the Forced Immobilization Test but not in spontaneous RLS or PLMS at night. These results are discussed in view of the possible involvement of the dopaminergic mechanism in RLS/PLMS syndrome.
我们在此报告阿片类药物对一名表现出特别严重的不宁腿综合征（RLS）及睡眠期周期性腿部运动（PLMS）患者可能产生的影响。该患者在睡眠实验室接受了三种情况的研究，即未用药（基线）、使用硫酸可待因治疗以及同时使用硫酸可待因和匹莫齐特治疗。硫酸可待因显著改善了该患者的异常运动行为。在强迫固定试验中，添加匹莫齐特逆转了可待因的有益作用，但在夜间的自发性RLS或PLMS中并未逆转。鉴于多巴胺能机制可能参与RLS/PLMS综合征，对这些结果进行了讨论。
