氯硝西泮对睡眠中周期性腿部运动影响的双盲评估。
Double-blind evaluation of clonazepam on periodic leg movements in sleep.
作者信息
Peled R, Lavie P
机构信息
Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
出版信息
J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1679-81. doi: 10.1136/jnnp.50.12.1679.
Abstract
Treatment with clonazepam was studied in a group of 20 patients suffering from periodic movements in sleep, in a double-blind parallel group design. Eleven complained of excessive daytime sleepiness, and nine complained of insomnia. Ten patients received clonazepam, and 10 received placebo, over a period of 1 month. Clonazepam (0.5-2 mg per night) proved to be an effective treatment of periodic movements in sleep. Polysomnographic recordings demonstrated a significant decrease in the number of leg movements and a significant improvement in sleep parameters in the clonazepam group as compared with placebo. Subjective responses to treatment corroborated the sleep laboratory findings.
摘要
采用双盲平行组设计，对一组20例患有睡眠期周期性肢体运动的患者进行了氯硝西泮治疗研究。11例主诉白天过度嗜睡，9例主诉失眠。10例患者接受氯硝西泮治疗，10例接受安慰剂治疗，为期1个月。结果证明，氯硝西泮（每晚0.5 - 2毫克）是治疗睡眠期周期性肢体运动的有效药物。多导睡眠图记录显示，与安慰剂组相比，氯硝西泮组的腿部运动次数显著减少，睡眠参数显著改善。对治疗的主观反应证实了睡眠实验室的研究结果。
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