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本文引用的文献

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Nocturnal myoclonus.夜间肌阵挛
J Neurol Neurosurg Psychiatry. 1953 Aug;16(3):166-71. doi: 10.1136/jnnp.16.3.166.
2
Periodic movements in sleep (nocturnal myoclonus): relation to sleep disorders.睡眠中的周期性运动（夜间肌阵挛）：与睡眠障碍的关系。
Ann Neurol. 1980 Oct;8(4):416-21. doi: 10.1002/ana.410080413.
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Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile.智利克雅氏病的描述性流行病学
Arch Neurol. 1980 Jan;37(1):11-4. doi: 10.1001/archneur.1980.00500500041004.
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Effect of baclofen on sleep-related periodic leg movements.巴氯芬对睡眠相关周期性腿部运动的影响。
Ann Neurol. 1984 Mar;15(3):234-9. doi: 10.1002/ana.410150304.
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Periodic movements during sleep, sleep fragmentation, and sleep-wake complaints.睡眠期间的周期性运动、睡眠片段化及睡眠-觉醒相关主诉。
Sleep. 1984;7(4):326-30. doi: 10.1093/sleep/7.4.326.
6
[Apropos of some nocturnal myoclonic manifestations. (Symonds' nocturnal myoclonus)].关于一些夜间肌阵挛表现。（西蒙兹夜间肌阵挛）
Rev Neurol (Paris). 1966 Sep;115(3):547-55.
7
Periodic leg movements in sleep: effect of clonazepam treatment.睡眠期周期性腿部运动：氯硝西泮治疗的效果
Neurology. 1985 Mar;35(3):408-11. doi: 10.1212/wnl.35.3.408.
8
Periodic movements in sleep and sleep-wake complaint.睡眠中的周期性运动与睡眠-觉醒障碍
Sleep. 1985 Dec;8(4):319-24. doi: 10.1093/sleep/8.4.319.
9
Nocturnal myoclonus: treatment efficacy of clonazepam and temazepam.夜间肌阵挛：氯硝西泮和替马西泮的治疗效果
Sleep. 1986;9(3):385-92. doi: 10.1093/sleep/9.3.385.
10
Sleep-related periodic myoclonus in patients complaining of insomnia.主诉失眠患者的睡眠相关性周期性肌阵挛
Trans Am Neurol Assoc. 1975;100:19-22.

氯硝西泮对睡眠中周期性腿部运动影响的双盲评估。

Double-blind evaluation of clonazepam on periodic leg movements in sleep.

作者信息

Peled R, Lavie P

机构信息

Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.

出版信息

J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1679-81. doi: 10.1136/jnnp.50.12.1679.

DOI:10.1136/jnnp.50.12.1679
PMID:3437302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032613/
Abstract

Treatment with clonazepam was studied in a group of 20 patients suffering from periodic movements in sleep, in a double-blind parallel group design. Eleven complained of excessive daytime sleepiness, and nine complained of insomnia. Ten patients received clonazepam, and 10 received placebo, over a period of 1 month. Clonazepam (0.5-2 mg per night) proved to be an effective treatment of periodic movements in sleep. Polysomnographic recordings demonstrated a significant decrease in the number of leg movements and a significant improvement in sleep parameters in the clonazepam group as compared with placebo. Subjective responses to treatment corroborated the sleep laboratory findings.

摘要

采用双盲平行组设计，对一组20例患有睡眠期周期性肢体运动的患者进行了氯硝西泮治疗研究。11例主诉白天过度嗜睡，9例主诉失眠。10例患者接受氯硝西泮治疗，10例接受安慰剂治疗，为期1个月。结果证明，氯硝西泮（每晚0.5 - 2毫克）是治疗睡眠期周期性肢体运动的有效药物。多导睡眠图记录显示，与安慰剂组相比，氯硝西泮组的腿部运动次数显著减少，睡眠参数显著改善。对治疗的主观反应证实了睡眠实验室的研究结果。