Wolffe A P, Brown D D
Cell. 1986 Oct 24;47(2):217-27. doi: 10.1016/0092-8674(86)90444-7.
Replication of the Xenopus laevis 5S RNA gene in vitro is unimpeded by the presence of a complete transcription complex assembled on the internal control region of the gene. The transcription complex is disrupted by passage of the replication fork, specific transcription factors are displaced, and the daughter 5S RNA genes are inactivated. We have been unable to demonstrate that any "memory" of the preexisting transcription complex is transmitted to the daughter DNA duplexes following replication.
非洲爪蟾5S RNA基因在体外的复制不受在该基因内部控制区组装的完整转录复合体存在的阻碍。转录复合体在复制叉通过时被破坏，特定转录因子被取代，并且子代5S RNA基因失活。我们未能证明在复制后，任何对先前存在的转录复合体的“记忆”被传递给子代DNA双链体。
