Zhu Di, Zhong Jihua, Zhang Yiwei, Chen Fangyuan
Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China.
Exp Ther Med. 2018 Oct;16(4):3161-3164. doi: 10.3892/etm.2018.6556. Epub 2018 Aug 1.
Few studies to date have reported on the myelodysplastic features of children with juvenile idiopathic arthritis (JIA). Bone marrow specimens were collected from 107 patients aged from 7-12 years who were initially diagnosed with JIA between May 2013 and October 2015. In 107 patients with JIA, bone marrow proliferation was higher than normal and hemophagocytes were more easily observed than usual. The characteristics of bone marrow cells in 107 patients with JIA were investigated and the associations of these characteristics with the disease was discussed in the present study. It was noticed that there were similar changes in the myeloid, erythropoietic and megakaryopoietic series in the majority of bone marrow specimens; the presence of hemophagocytes was also reported. The present findings suggest that JIA is associated with specific myelodysplastic changes, and that cellular immune system dysfunction and overreactive inflammatory cytokines may contribute to the development of these myelodysplastic changes in the bone marrow.
迄今为止，很少有研究报道幼年特发性关节炎（JIA）患儿的骨髓发育异常特征。收集了2013年5月至2015年10月期间最初诊断为JIA的107例7至12岁患者的骨髓标本。在107例JIA患者中，骨髓增殖高于正常水平，且比通常更容易观察到噬血细胞。本研究对107例JIA患者的骨髓细胞特征进行了调查，并讨论了这些特征与该疾病的关联。注意到大多数骨髓标本中髓系、红系和巨核系存在相似变化；也有噬血细胞存在的报道。目前的研究结果表明，JIA与特定的骨髓发育异常变化有关，细胞免疫系统功能障碍和过度活跃的炎性细胞因子可能促成骨髓中这些骨髓发育异常变化的发生。
