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一名日本年轻女性因脂蛋白脂肪酶和肝甘油三酯脂肪酶活性水平降低，导致非酒精性脂肪性肝炎并发严重急性胰腺炎的病例。

A case of non-alcoholic steatohepatitis complicated with severe acute pancreatitis induced by decreased lipoprotein lipase and hepatic triglyceride lipase activity levels in a young Japanese woman.

作者信息

Minohara Sawa, Bae Sung Kwan, Sugiyama Saori, Shibata Noriko, Gushima Toshifumi, Motoshita Junichi, Shimoda Shinji, Takagi Atsuko, Ikeda Yasuyuki, Takahashi Kazuhiro

机构信息

The Center for Liver Disease Hamanomachi Hospital Chuo-ku, Fukuoka Japan.

Department of Pathology Hamanomachi Hospital Fukuoka Japan.

出版信息

Clin Case Rep. 2018 Jul 18;6(9):1769-1773. doi: 10.1002/ccr3.1706. eCollection 2018 Sep.

DOI:10.1002/ccr3.1706
PMID:30214760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6132095/
Abstract

We report a case of non-alcoholic steatohepatitis complicated with acute pancreatitis induced by hypertriglyceridemia in a young Japanese woman. A precise examination of the lipid profile showed decreased lipoprotein lipase (LPL) and hepatic triglyceride lipase activity levels, while the LPL mass was at the minimum level of the normal range.

摘要

我们报告了一例年轻日本女性非酒精性脂肪性肝炎合并高甘油三酯血症诱发的急性胰腺炎的病例。对血脂谱的精确检测显示脂蛋白脂肪酶（LPL）和肝甘油三酯脂肪酶活性水平降低，而LPL质量处于正常范围的最低水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7a/6132095/3a549ed730a7/CCR3-6-1769-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7a/6132095/1c3c5f8e1fbd/CCR3-6-1769-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7a/6132095/3a549ed730a7/CCR3-6-1769-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7a/6132095/1c3c5f8e1fbd/CCR3-6-1769-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7a/6132095/3a549ed730a7/CCR3-6-1769-g002.jpg

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Type 1 Hyperlipoproteinemia Due to Compound Heterozygous Rare Variants in GCKR.由于GCKR基因复合杂合罕见变异导致的I型高脂蛋白血症
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A case of adolescent hyperlipoproteinemia with xanthoma and acute pancreatitis, associated with decreased activities of lipoprotein lipase and hepatic triglyceride lipase.一例伴有黄瘤和急性胰腺炎的青少年高脂蛋白血症，与脂蛋白脂肪酶和肝甘油三酯脂肪酶活性降低有关。
Intern Med. 2010;49(22):2467-72. doi: 10.2169/internalmedicine.49.4058. Epub 2010 Nov 15.
7
Design and validation of a histological scoring system for nonalcoholic fatty liver disease.非酒精性脂肪性肝病组织学评分系统的设计与验证
Hepatology. 2005 Jun;41(6):1313-21. doi: 10.1002/hep.20701.
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Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions.非酒精性脂肪性肝炎：关于组织学病变分级和分期的建议。
Am J Gastroenterol. 1999 Sep;94(9):2467-74. doi: 10.1111/j.1572-0241.1999.01377.x.
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