术前给予依库珠单抗以预防阵发性夜间血红蛋白尿患者剖宫产手术引发的溶血。
Preoperative administration of eculizumab to prevent surgery-triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria.
作者信息
Li Dongping, Wang Liangcheng, Horiuchi Isao, Kimura Shun-Ichi, Chikazawa Kenro, Kimura Azusa, Sasaki Shigetane, Kuwata Tomoyuki, Takagi Kenjiro
机构信息
Perinatal and Maternal Center of Saitama Medical Center Jichi Medical University Saitama Japan.
Division of Hematology Saitama Medical Center Jichi Medical University Saitama Japan.
出版信息
Clin Case Rep. 2018 Jul 25;6(9):1807-1809. doi: 10.1002/ccr3.1707. eCollection 2018 Sep.
Eculizumab in pregnancy has been reported to be effective in improving outcomes in patients with paroxysmal nocturnal hemoglobinuria. However, a cesarean section may result in surgery-triggered hemolysis. An additional dose of eculizumab just prior to delivery is an appropriate choice to prevent postoperative hemolysis.
据报道，妊娠期间使用依库珠单抗可有效改善阵发性夜间血红蛋白尿患者的预后。然而，剖宫产可能会导致手术引发的溶血。在分娩前额外注射一剂依库珠单抗是预防术后溶血的合适选择。
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