接受依库珠单抗治疗阵发性夜间血红蛋白尿症的女性的妊娠结局。
Pregnancy outcomes in women receiving eculizumab for the management of paroxysmal nocturnal haemoglobinuria.
作者信息
Manning James E, Anderson Rachel M, Hill Anita, Zeidan Doaa, Ciantar Etienne
机构信息
School of Medicine, University of Leeds, Leeds, UK.
Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
出版信息
Obstet Med. 2022 Mar;15(1):45-49. doi: 10.1177/1753495X211019899. Epub 2021 Jun 20.
Abstract
AIMS
To report pregnancy outcomes and complications in women receiving eculizumab for the management of paroxysmal nocturnal haemoglobinuria.
METHODS
A service evaluation of routinely collected medical records across 49 pregnancies in 21 women.
RESULTS
Eculizumab was used in 37 pregnancies, 31 of which (83.8%) ended in live birth. Eight infants (25.8%) were born prematurely. Over half (54%) of women required increases in their dose of eculizumab to control their haemolysis. There were no reported cases of maternal thrombosis. Major ante/postpartum bleeding necessitating urgent intervention was reported in 10.8% of pregnancies. There were two cases of intrauterine death and three miscarriages. There were no maternal or neonatal deaths. Three newborns required prolonged hospital stays.
CONCLUSIONS
Eculizumab appears to benefit pregnant women with paroxysmal nocturnal haemoglobinuria and pregnancy outcomes following its use are largely good.
摘要
目的
报告接受依库珠单抗治疗阵发性夜间血红蛋白尿症的女性的妊娠结局及并发症。
方法
对21名女性的49次妊娠的常规收集病历进行服务评估。
结果
37次妊娠使用了依库珠单抗，其中31次（83.8%）以活产告终。8名婴儿（25.8%）早产。超过一半（54%）的女性需要增加依库珠单抗剂量以控制溶血。未报告有母亲血栓形成的病例。10.8%的妊娠报告有需要紧急干预的严重产前/产后出血。有2例宫内死亡和3例流产。无孕产妇或新生儿死亡。3名新生儿需要延长住院时间。
结论
依库珠单抗似乎使患有阵发性夜间血红蛋白尿症的孕妇受益，使用后的妊娠结局总体良好。
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