Ahtola Eero, Stjerna Susanna, Stevenson Nathan, Vanhatalo Sampsa
Department of Children's Clinical Neurophysiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
Clin Neurophysiol Pract. 2017 Mar 21;2:81-90. doi: 10.1016/j.cnp.2017.03.002. eCollection 2017.
To improve the reliability of detecting EEG responses evoked by complex visual stimuli to the level required for clinical use by integrating an eye tracker to the EEG setup and optimizing the analysis protocol.
Infants were presented with continuous orientation reversal (OR), global form (GF), and global motion (GM) stimuli. Eye tracking was used to control stimulus presentation and exclude epochs with disoriented gaze. The spectral responses were estimated from 13 postcentral EEG channels using a circular variant of Hotelling's T test statistic.
Among 39 healthy infants, statistically significant (p < 0.01) responses to OR/GF/GM stimuli were found from 92%/100%/95% recordings, respectively. The specificity test of the detection algorithm, using non-stimulated baseline EEG, did not yield any false-positive findings. Taken together, this yields 15% improvement on average in the detection performance compared to that in the current literature.
Changes to the test protocol and incorporation of the eye tracking information improves the detection of responses to complex visual stimuli in infants.
This work presents a test protocol suitable for use in a clinical environment at a level of reliability that allows individual diagnostics.
通过将眼动追踪仪集成到脑电图（EEG）设置中并优化分析方案，将检测复杂视觉刺激诱发的EEG反应的可靠性提高到临床应用所需的水平。
向婴儿呈现连续的方向反转（OR）、整体形状（GF）和整体运动（GM）刺激。使用眼动追踪来控制刺激呈现，并排除注视方向错误的时段。使用霍特林T检验统计量的圆形变体从13个中央后EEG通道估计频谱反应。
在39名健康婴儿中，分别在92%/100%/95%的记录中发现了对OR/GF/GM刺激具有统计学显著意义（p < 0.01）的反应。使用未受刺激的基线EEG对检测算法进行的特异性测试未产生任何假阳性结果。总体而言，与当前文献相比，检测性能平均提高了15%。
测试方案的改变以及眼动追踪信息的纳入提高了对婴儿复杂视觉刺激反应的检测能力。
这项工作提出了一种适用于临床环境的测试方案，其可靠性水平允许进行个体诊断。
