Poniedziałek-Czajkowska Elżbieta, Mierzyński Radzisław, Słodzińska Magdalena, Dłuski Dominik, Leszczyńska-Gorzelak Bożena
Klinika Położnictwa i Perinatologii Samodzielnego Publicznego Szpitala Klinicznego nr 4 w Lublinie.
Ginekol Pol. 2018;89(8):442-48. doi: 10.5603/GP.a2018.0076.
The aim of the study was to evaluate the levels of adipokines such as adiponectin, resistin, leptin as well as C-peptide in overweight and obese pregnant women.
The adipokines and C-peptide concentrations were measured in the group of 38 overweight/obese pregnant women (BMI > 25 kg/m2) and in 42 pregnant women of normal weight (BMI < 25 kg/m2) with ELISA tests between 24th and 34th weeks of gestation.
The overweight/obese women compared to lean ones were characterized by significantly higher concentrations of leptin (43.44 ± 31.41 vs. 21.29 ± 12.67 ng/mL, p = 0.0001) and C-peptide (2.77 ± 1.88 vs. 2.25 ± 1.42 ng/mL, p = 0.034). There were no significant differences between groups in resistin (17.39 ± 7.59 vs. 15.76 ± 6.64 ng/mL, NS) and adiponectin (6.93 ± 3.52 vs. 8.07 ± 6.53 μg/mL, NS) levels. In the overweight/obese patients, no relationships between the adipokines, C-peptide and CRP concentrations were found. BMI was negatively correlated with the resistin levels (R = -0.406, p = 0.011). The significant correlation between leptin and C-peptide concentrations was observed in the study group (R = 0.517, p = 0.012). In the control group, the negative correlation between adiponectin concentrations and BMI was shown (R = -0.446, p = 0.003).
The higher levels of leptin in the overweight and obese pregnant women seem to reflect the leptin resistance condition and the higher levels of C-peptide in this group is suggestive for hyperinsulinemia. The positive correlation between C-peptide and leptin levels but not with resistin and adiponectin might confirm the role of leptin in the hyperinsulinemia development in overweight and obesity during pregnancy.
本研究旨在评估超重及肥胖孕妇体内脂联素、抵抗素、瘦素等脂肪因子以及C肽的水平。
采用酶联免疫吸附测定法（ELISA），对38名超重/肥胖孕妇（BMI>25kg/m²）和42名体重正常的孕妇（BMI<25kg/m²）在妊娠24至34周期间的脂肪因子和C肽浓度进行了检测。
与体重正常的孕妇相比，超重/肥胖孕妇体内的瘦素（43.44±31.41 vs. 21.29±12.67 ng/mL，p = 0.0001）和C肽（2.77±1.88 vs. 2.25±1.42 ng/mL，p = 0.034）浓度显著更高。两组孕妇的抵抗素（17.39±7.59 vs. 15.76±6.64 ng/mL，无显著差异）和脂联素（6.93±3.52 vs. 8.07±6.53 μg/mL，无显著差异）水平无显著差异。在超重/肥胖患者中，未发现脂肪因子、C肽与CRP浓度之间存在关联。BMI与抵抗素水平呈负相关（R = -0.406，p = 0.011）。研究组中观察到瘦素与C肽浓度之间存在显著相关性（R = 0.517，p = 0.012）。在对照组中，脂联素浓度与BMI呈负相关（R = -0.446，p = 0.003）。
超重及肥胖孕妇体内较高的瘦素水平似乎反映了瘦素抵抗状态，而该组中较高的C肽水平提示存在高胰岛素血症。C肽与瘦素水平呈正相关，但与抵抗素和脂联素无关，这可能证实了瘦素在孕期超重和肥胖患者高胰岛素血症发展过程中的作用。
