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Regeneration of osteochondral defects in vivo by a cell-free cylindrical poly(lactide-co-glycolide) scaffold with a radially oriented microstructure.利用具有放射状微结构的无细胞圆柱状聚（丙交酯-共-乙交酯）支架在体内再生骨软骨缺损。
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Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration.纤维内硅化胶原支架调节单核细胞促进细胞归巢、血管生成和骨再生。
Biomaterials. 2017 Jan;113:203-216. doi: 10.1016/j.biomaterials.2016.10.050. Epub 2016 Oct 31.
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Tunable Controlled Release of Bioactive SDF-1α via Protein Specific Interactions within Fibrin/Nanoparticle Composites.通过纤维蛋白/纳米颗粒复合材料内的蛋白质特异性相互作用实现生物活性SDF-1α的可调控释放
J Mater Chem B. 2015 Oct 31;3(40):7963-7973. doi: 10.1039/C5TB00935A. Epub 2015 Aug 11.
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A new method of wound treatment: targeted therapy of skin wounds with reactive oxygen species-responsive nanoparticles containing SDF-1α.一种伤口治疗的新方法：用含有SDF-1α的活性氧响应纳米颗粒对皮肤伤口进行靶向治疗。
Int J Nanomedicine. 2015 Oct 19;10:6571-85. doi: 10.2147/IJN.S88384. eCollection 2015.
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Combination of granulocyte colony-stimulating factor and CXCR4 antagonist AMD3100 for effective harvest of endothelial progenitor cells from peripheral blood and in vitro formation of primitive endothelial networks.粒细胞集落刺激因子与CXCR4拮抗剂AMD3100联合应用可有效从外周血中获取内皮祖细胞并在体外形成原始内皮网络。
Cell Tissue Bank. 2016 Mar;17(1):161-9. doi: 10.1007/s10561-015-9527-4. Epub 2015 Jul 31.
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3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions.将负载人胚肾 293FT 细胞的水凝胶 3D 打印成具有高细胞活力和正常生物学功能的大孔构建体。
Biofabrication. 2015 Feb 18;7(1):015010. doi: 10.1088/1758-5090/7/1/015010.
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Preparation and characterization of SDF-1α-chitosan-dextran sulfate nanoparticles.基质细胞衍生因子-1α-壳聚糖-硫酸葡聚糖纳米粒的制备与表征
J Vis Exp. 2015 Jan 22(95):52323. doi: 10.3791/52323.
8
Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing.具有 SDF-1 的放射状取向胶原支架通过促进细胞归巢促进骨软骨修复。
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Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone.在掺锶聚磷酸钙支架上进行外周血源性间充质干细胞与内皮祖细胞的共培养以生成血管化工程骨。
Tissue Eng Part A. 2015 Mar;21(5-6):948-59. doi: 10.1089/ten.TEA.2014.0267. Epub 2014 Nov 17.
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Systemically transplanted human gingiva-derived mesenchymal stem cells contributing to bone tissue regeneration.全身移植的人牙龈间充质干细胞促进骨组织再生。
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[组织工程技术在骨与软骨修复中的应用及研究进展]

[The application and research progress of tissue engineering technology in bone and cartilage repair].

作者信息

Xing Fei, Li Lang, Liu Ming, Duan Xin, Long Ye, Xiang Zhou

机构信息

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

出版信息

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Oct 15;32(10):1358-1364. doi: 10.7507/1002-1892.201712118.

DOI:10.7507/1002-1892.201712118
PMID:30215487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8414144/
Abstract

OBJECTIVE

To review the application and research progress of tissue engineering technology in bone and cartilage repair.

METHODS

The original articles about tissue engineering technology in bone and cartilage repair were extensively reviewed and analyzed.

RESULTS

tissue engineering have been shown to be effective in repairing bone defects and cartilage defects, but biological mechanisms are inadequate. At present, most of researches are mainly focused on animal experiments, and the effect of clinical repair need to be further studied.

CONCLUSION

tissue engineering technology has wide application prospects in bone and cartilage tissue engineering. However, further study on the mechanism of related cytokines need to be conducted.

摘要

目的

综述组织工程技术在骨与软骨修复中的应用及研究进展。

方法

广泛查阅并分析有关组织工程技术在骨与软骨修复方面的原始文献。

结果

组织工程已被证明在修复骨缺损和软骨缺损方面有效，但生物学机制尚不充分。目前，大多数研究主要集中在动物实验上，临床修复效果有待进一步研究。

结论

组织工程技术在骨与软骨组织工程中具有广阔的应用前景。然而，需要对相关细胞因子的机制进行进一步研究。