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[细胞片技术在骨与软骨组织工程中的应用]

[Application of cell sheet technology in bone and cartilage tissue engineering].

作者信息

Zhi Zhenya, Xing Fei, Chen Long, Li Lang, Long Ye, Xiang Zhou

机构信息

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

出版信息

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Feb 15;32(2):237-241. doi: 10.7507/1002-1892.201707027.

Abstract

OBJECTIVE

To review the progress of cell sheet technology and its application in bone and cartilage engineering.

METHODS

The recent literature concerning the cell sheet technology used in treatment of bone and cartilage defects was extensively reviewed and summarized.

RESULTS

Cell sheet built through many different ways can protect extracellular matrix from proteolytic enzymes. As a three-dimensional structure, cell sheet can repair bone and cartilige defects via folding, wrapping scaffold, or be created by the layering of individual cell sheets.

CONCLUSION

The cell sheet technology would have a very broad prospects in bone and cartilage tissue engineering in future.

摘要

目的

综述细胞片技术及其在骨与软骨组织工程中的应用进展。

方法

广泛查阅并总结近期有关细胞片技术用于治疗骨与软骨缺损的文献。

结果

通过多种不同方式构建的细胞片可保护细胞外基质免受蛋白水解酶的破坏。作为一种三维结构,细胞片可通过折叠、包裹支架或逐层叠加单个细胞片来修复骨与软骨缺损。

结论

细胞片技术在未来骨与软骨组织工程中具有非常广阔的前景。

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[Application of cell sheet technology in bone and cartilage tissue engineering].[细胞片技术在骨与软骨组织工程中的应用]
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Assessment of the Safety of Chondrocyte Sheet Implantation for Cartilage Regeneration.软骨细胞片植入用于软骨再生的安全性评估。
Tissue Eng Part C Methods. 2016 Jan;22(1):59-68. doi: 10.1089/ten.TEC.2015.0254. Epub 2015 Dec 18.

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