Center of Clinical Laboratory Science, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, PR China.
Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, PR China.
Epigenomics. 2018 Oct;10(10):1301-1313. doi: 10.2217/epi-2017-0173. Epub 2018 Sep 14.
We aimed to explore the roles of circRNAs in gastric cancer.
MATERIALS & METHODS: The dysregulated circRNAs and miRNAs were identified using data from Gene Expression Omnibus. The roles of specifically selected circRNAs were explored. Survival analysis was performed using data from the Cancer Genome Atlas.
We identified 68 dysregulated circRNAs and 51 dysregulated miRNAs. We found that hsa_circ_0000993 inhibited migration, invasion and proliferation of gastric cancer cells and could act as a miRNA sponge for miR-214-5p but did not modulate expression of its parental gene, ATL2. Survival analysis showed that gastric cancer patients with lowly expressed miR-214-5p had a significantly better overall survival.
In conclusion, hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p.
我们旨在探索 circRNAs 在胃癌中的作用。
使用来自基因表达综合数据库的数据鉴定失调的 circRNAs 和 miRNAs。探索特定选择的 circRNAs 的作用。使用癌症基因组图谱的数据进行生存分析。
我们鉴定出 68 个失调的 circRNAs 和 51 个失调的 miRNAs。我们发现 hsa_circ_0000993 抑制胃癌细胞的迁移、侵袭和增殖，并且可以作为 miR-214-5p 的 miRNA 海绵，但不调节其亲本基因 ATL2 的表达。生存分析显示，miR-214-5p 低表达的胃癌患者总生存率显著提高。
总之，hsa_circ_0000993 可能通过隔离 miR-214-5p 来抑制胃癌的转移。
