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环状ATRNL1和环状ZNF608通过隔离miR-152-5p和编码蛋白质来抑制卵巢癌。

CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein.

作者信息

Lyu Mengmeng, Li Xiujuan, Shen Yang, Lu Jin, Zhang Lihua, Zhong Shanliang, Wang Jinhua

机构信息

Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China.

Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China.

出版信息

Front Genet. 2022 Feb 23;13:784089. doi: 10.3389/fgene.2022.784089. eCollection 2022.

DOI:10.3389/fgene.2022.784089
PMID:35281849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8905624/
Abstract

CircRNAs have been found to be involved in the pathogenesis of various diseases. We aimed to explore the roles of circRNAs in ovarian cancer. The expression levels of circRNAs in ovarian cancer and normal ovarian tissues were analyzed using RNA sequencing. Fluorescent hybridization (FISH), proliferation assays and transwell assays were used to assess the effects of circRNAs on ovarian cancer. CircATRNL1 and circZNF608 were downregulated in 20 ovarian cancer tissues compared to normal tissues. CircATRNL1 and circZNF608 are mainly located in the cytoplasm of ovarian cancer cells, and circATRNL1 is a highly conserved circRNA. The overexpression of circATRNL1 and circZNF608 inhibits the proliferation and invasion of ovarian cancer cells. We predicted miRNA-circRNA interactions for circZNF608 and circATRNL1 and obtained 63 interactions. However, a luciferase reporter assay showed that only miR-152-5p was sequestered by circZNF608. Bioinformatics analysis and experiments indicated that circATRNL1 contains an internal ribosome entry site and an open reading frame encoding a 131 aa protein. In conclusion, circATRNL1 and circZNF608 are two downregulated circRNAs in ovarian cancer and work as tumor suppressors. CircZNF608 may exert antitumor activity in ovarian cancer by binding miR-152-5p, and circATRNL1 may encode a 131 aa protein.

摘要

环状RNA（circRNAs）已被发现参与多种疾病的发病机制。我们旨在探讨circRNAs在卵巢癌中的作用。使用RNA测序分析了卵巢癌组织和正常卵巢组织中circRNAs的表达水平。采用荧光杂交（FISH）、增殖试验和Transwell试验来评估circRNAs对卵巢癌的影响。与正常组织相比，20例卵巢癌组织中circATRNL1和circZNF608表达下调。circATRNL1和circZNF608主要位于卵巢癌细胞的细胞质中，且circATRNL1是一种高度保守的circRNA。circATRNL1和circZNF608的过表达抑制卵巢癌细胞的增殖和侵袭。我们预测了circZNF608和circATRNL1的miRNA-circRNA相互作用，共获得63种相互作用。然而，荧光素酶报告基因试验表明，只有miR-152-5p被circZNF608所吸附。生物信息学分析和实验表明，circATRNL1含有一个内部核糖体进入位点和一个编码131个氨基酸蛋白的开放阅读框。总之，circATRNL1和circZNF608是卵巢癌中两个表达下调的circRNAs，起肿瘤抑制作用。circZNF608可能通过结合miR-152-5p在卵巢癌中发挥抗肿瘤活性，而circATRNL1可能编码一种131个氨基酸的蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/b42ba9547143/fgene-13-784089-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/59f1a60437c4/fgene-13-784089-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/2b4945a32393/fgene-13-784089-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/32b587392e90/fgene-13-784089-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/b42ba9547143/fgene-13-784089-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/59f1a60437c4/fgene-13-784089-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/2b4945a32393/fgene-13-784089-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/32b587392e90/fgene-13-784089-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c0/8905624/b42ba9547143/fgene-13-784089-g004.jpg

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