铜催化合成 2-氨基苯基苯并噻唑：一种新方法。
Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach.
机构信息
Department of Chemistry, Acharya Nagarjuna University, N Nagar, Guntur, A. P-522510, India.
出版信息
Org Biomol Chem. 2018 Sep 26;16(37):8267-8272. doi: 10.1039/c8ob02018c.
A novel, convenient and efficient protocol for the construction of various 2-aminophenyl benzothiazoles by domino intra- and intermolecular C-N cross-coupling reactions of arylisothioureas with aryl iodides using an inexpensive, air stable and readily available copper catalyst is described. The arylisothioureas were obtained from thiourea via copper promoted desulfurization followed by nucleophilic substitution. In addition, the reactivity of arylhalides and the reaction mechanism have also been studied. The protocol features operational simplicity and a broad substrate scope.
本文描述了一种新颖、简便、高效的方法，通过铜催化的廉价、稳定、易得的铜催化剂，通过芳基异硫脲与芳基碘化物的分子内和分子间的 C-N 交叉偶联反应，构建了各种 2-氨基苯基苯并噻唑。芳基异硫脲是通过硫脲的铜促进脱硫和亲核取代反应得到的。此外，还研究了芳基卤化物的反应性和反应机理。该方法具有操作简单、底物范围广泛的特点。
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