霍奇金淋巴瘤缓解期持续存在的淋巴细胞缺陷
Persisting lymphocyte deficiences during remission in Hodgkin's disease.
作者信息
Björkholm M, Holm G, Mellstedt H
出版信息
Clin Exp Immunol. 1977 Jun;28(3):389-93.
Abstract
Blood lymphocytes from nineteen patients with Hodgkin's disease were tested in vitro before and after treatment. The patients were retested in complete and unmaintained remission at least 15 months after termination of radiotherapy. All patients except two had been treated with total nodal irradiation. The lymphocyte-DNA synthesis induced by concanavalin A (Con A) and PPD was poor and the spontaneous DNA synthesis was increased in untreated patients. Most patients had a T lymphocytopenia before treatment. After irradiation the total lymphocyte counts were reduced drastically. The number of T lymphocytes was particularly low, though the number of B lymphocytes decreased as well. However, the lymphocyte response to Con A and PPD remained low and unchanged. The results may suggest a persisting immunodeficiency in Hodgkin's disease as reflected by the lymphocyte response to Con A and PPD.
摘要
对19例霍奇金病患者治疗前后的血液淋巴细胞进行了体外检测。患者在放疗结束后至少15个月处于完全缓解且未接受维持治疗时再次接受检测。除2例患者外，所有患者均接受了全淋巴结照射。未治疗患者中，伴刀豆球蛋白A（Con A）和结核菌素纯蛋白衍生物（PPD）诱导的淋巴细胞DNA合成较差，且自发DNA合成增加。大多数患者治疗前存在T淋巴细胞减少。放疗后淋巴细胞总数急剧减少。T淋巴细胞数量尤其低，尽管B淋巴细胞数量也减少。然而，淋巴细胞对Con A和PPD的反应仍然较低且未改变。这些结果可能提示霍奇金病存在持续的免疫缺陷，这可通过淋巴细胞对Con A和PPD的反应体现出来。
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