霍奇金病中的B淋巴细胞和T淋巴细胞。诊断时及治疗后的分析。
B and T lymphocytes in Hodgkin's disease. Analysis at diagnosis and following therapy.
作者信息
Gajl-Peczalska K J, Bloomfield C D, Sosin H, Kersey J H
出版信息
Clin Exp Immunol. 1976 Jan;23(1):47-55.
B and T lymphocytes were studied in the blood and lymph nodes of fifty patients with Hodgkin's disease. At diagnosis, most patients (77%) had normal percentages of circulating B and T lymphocytes. Most patients (60%) also showed normal percentages of B and T lymphocytes in involved lymph nodes. Splenectomy had no effect on circulating B and T lymphocytes in four of five patients studied 2 weeks postoperatively. Seventeen patients were studied before and after treatment to determine the effect of therapy. Very high percentages of B lymphocytes were found in patients studied following radiotherapy. It appears that the known defects in cell-mediated immunity in Hodgkin's disease are not expressed as significant abnormalities in B-or T-lymphocyte ratios in blood or lymphoid tissues at diagnosis. The proliferation of B lymphocytes following radiotherapy could represent a compensatory mechanism to cell-mediated deficiency or a loss of normal suppressor activity of T lymphocytes.
对50例霍奇金病患者的血液和淋巴结中的B淋巴细胞和T淋巴细胞进行了研究。在诊断时，大多数患者（77%）循环B淋巴细胞和T淋巴细胞的百分比正常。大多数患者（60%）受累淋巴结中的B淋巴细胞和T淋巴细胞百分比也正常。在术后2周对5例患者中的4例进行研究，结果显示脾切除术对循环B淋巴细胞和T淋巴细胞没有影响。对17例患者在治疗前后进行了研究，以确定治疗效果。在接受放射治疗后的患者中发现了非常高比例的B淋巴细胞。看来，霍奇金病中已知的细胞介导免疫缺陷在诊断时并未表现为血液或淋巴组织中B淋巴细胞或T淋巴细胞比例的显著异常。放射治疗后B淋巴细胞的增殖可能代表了对细胞介导缺陷的一种代偿机制，或者是T淋巴细胞正常抑制活性的丧失。
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