Túri S, Havass Z, Bodrogi T
Int Urol Nephrol. 1986;18(3):321-5. doi: 10.1007/BF02082721.
Urinary prostaglandin E (PGE) and cyclic AMP (cAMP) excretions were studied by radioimmunoassay in children with nephrotic syndrome and in a control population. In cases with nephrotic syndrome there was a significant elevation in urinary PGE excretion and cAMP excretion was decreased. A positive correlation was found between urinary cAMP excretion and urinary osmolality (Uosm) and the ratio urine to plasma osmolality (Uosm/Posm); and a negative correlation between urinary cAMP excretion and urine volume. A negative correlation was observed between the values of PGE excretion and urinary cAMP. These data confirmed the role of PGE as a modulator of cAMP production, which was inhibited in the nephrotic syndrome.
通过放射免疫分析法研究了肾病综合征患儿及对照人群的尿前列腺素E（PGE）和环磷酸腺苷（cAMP）排泄情况。肾病综合征患儿的尿PGE排泄显著升高，而cAMP排泄减少。尿cAMP排泄与尿渗透压（Uosm）以及尿与血浆渗透压比值（Uosm/Posm）呈正相关；尿cAMP排泄与尿量呈负相关。PGE排泄值与尿cAMP之间呈负相关。这些数据证实了PGE作为cAMP产生调节剂的作用，而在肾病综合征中这种作用受到抑制。
