2-脱氧-2-[¹⁸F]氟-D-葡萄糖和2-脱氧-2-[¹⁸F]氟-D-甘露糖的合成与纯化：通过¹H-和¹⁹F-NMR光谱对产物进行表征
Synthesis and purification of 2-deoxy-2-[18F]fluoro-D-glucose and 2-deoxy-2-[18F]fluoro-D-mannose: characterization of products by 1H- and 19F-NMR spectroscopy.
作者信息
Oberdorfer F, Hull W E, Traving B C, Maier-Borst W
出版信息
Int J Rad Appl Instrum A. 1986;37(8):695-701. doi: 10.1016/0883-2889(86)90263-7.
A procedure has been developed that allows the separation of 2-deoxy-2-[18F]fluoro-D-glucose from 2-deoxy-2-[18F]fluoro-D-mannose employing selectively optimized ion-moderated partition chromatography. Both compounds can be obtained with a greater than 98% chemical and radiochemical purity in about one half-life of 18F. Both the alpha- and beta-anomers of both sugars were completely characterized by high-resolution 1H- and 19F-NMR spectroscopy. Various convenient preparation methods for 2-deoxy-2-[18F]fluoro-D-glucose were compared.
已开发出一种方法，该方法采用选择性优化的离子调节分配色谱法从2-脱氧-2-[¹⁸F]氟-D-甘露糖中分离出2-脱氧-2-[¹⁸F]氟-D-葡萄糖。在¹⁸F的约一个半衰期内，两种化合物均可获得化学纯度和放射化学纯度均大于98%的产品。两种糖的α-和β-异头物均通过高分辨率¹H-和¹⁹F-NMR光谱进行了全面表征。比较了2-脱氧-2-[¹⁸F]氟-D-葡萄糖的各种便捷制备方法。
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