用于电化学传感的β-乳球蛋白功能化还原氧化石墨烯和三金属铂金钯纳米复合材料的简便合成
Facile Synthesis of β-Lactoglobulin-Functionalized Reduced Graphene Oxide and Trimetallic PtAuPd Nanocomposite for Electrochemical Sensing.
作者信息
Han Bingkai, Pan Meixin, Zhou Jiexin, Wang Yingying, Wang Zihua, Jiao Jun, Zhang Cong, Chen Qiang
机构信息
The Key Laboratory of Bioactive Materials Ministry of Education, College of Life Science, Nankai University, Weijin Road No. 94, Tianjin 300071, China.
Department of Chemistry, School of Sciences, Hebei University of Science and Technology, Shijiazhuang 050018, China.
出版信息
Nanomaterials (Basel). 2018 Sep 13;8(9):724. doi: 10.3390/nano8090724.
The use of graphene has leapt forward the materials field and the functional modification of graphene has not stopped. In this work, β-lactoglobulin (BLG) was used to functionalize reduced graphene oxide (RGO) based on its amphiphilic properties. Also, trimetallic PtAuPd nanoparticles were reduced to the surface of BLG-functionalized RGO and formed BLG-PtAuPd-RGO nanocomposite using facile synthesis. Transmission electron microscopy, energy-dispersive X-ray spectroscopy and Fourier transform infrared spectra were used to characterize the nanocomposite. Electrocatalytic analysis was evaluated through cyclic voltammetry and chronoamperometry methods. We developed a glucose sensor by fabricating GOD-BLG-PtAuPd-RGO/glassy carbon (GC) electrode. It presented a remarkable sensitivity of 63.29 μA mM cm (4.43 μA mM), a wider linear range from 0.005 to 9 mM and a lower detection limit of 0.13 μM (S/N = 3). Additionally, the glucose sensor exhibited excellent testing capability in human serum samples.
石墨烯的应用推动了材料领域的发展，并且对石墨烯的功能改性也从未停止。在这项工作中，基于β-乳球蛋白（BLG）的两亲性，将其用于还原氧化石墨烯（RGO）的功能化。此外，通过简便的合成方法，将三金属PtAuPd纳米颗粒还原到BLG功能化的RGO表面，形成BLG-PtAuPd-RGO纳米复合材料。利用透射电子显微镜、能量色散X射线光谱和傅里叶变换红外光谱对该纳米复合材料进行了表征。通过循环伏安法和计时电流法对电催化性能进行了评估。我们通过制备GOD-BLG-PtAuPd-RGO/玻碳（GC）电极开发了一种葡萄糖传感器。该传感器具有63.29 μA mM cm（4.43 μA mM）的显著灵敏度、0.005至9 mM的较宽线性范围以及0.13 μM的较低检测限（S/N = 3）。此外，该葡萄糖传感器在人血清样本中表现出优异的检测能力。
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