Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil.
Programa de Pos Graduação em Genetica e Biologia Molecular, State University of Campinas, Campinas, São Paulo 13083-881, Brazil.
Int J Mol Sci. 2018 Sep 13;19(9):2757. doi: 10.3390/ijms19092757.
Obesity is a health problem worldwide, and energy imbalance has been pointed out as one of the main factors responsible for its development. As mitochondria are a key element in energy homeostasis, the development of obesity has been strongly associated with mitochondrial imbalance. Polyphenols are the largest group of phytochemicals, widely distributed in the plant kingdom, abundant in fruits and vegetables, and have been classically described as antioxidants owing to their well-established ability to eliminate free radicals and reactive oxygen species (ROS). During the last decade, however, growing evidence reports the ability of polyphenols to perform several important biological activities in addition to their antioxidant activity. Special attention has been given to the ability of polyphenols to modulate mitochondrial processes. Thus, some polyphenols are now recognized as molecules capable of modulating pathways that regulate mitochondrial biogenesis, ATP synthesis, and thermogenesis, among others. The present review reports the main benefits of polyphenols in modulating mitochondrial processes that favor the regulation of energy expenditure and offer benefits in the management of obesity, especially thermogenesis and mitochondrial biogenesis.
肥胖是一个全球性的健康问题，能量失衡被指出是导致其发展的主要因素之一。由于线粒体是能量平衡的关键因素，肥胖的发展与线粒体失衡密切相关。多酚是植物化学物质中最大的一组，广泛分布于植物界，在水果和蔬菜中含量丰富，由于其消除自由基和活性氧（ROS）的能力已得到充分证实，因此经典上被描述为抗氧化剂。然而，在过去的十年中，越来越多的证据表明多酚除了具有抗氧化活性外，还具有多种重要的生物学活性。多酚调节线粒体过程的能力引起了特别关注。因此，一些多酚现在被认为是能够调节调节线粒体生物发生、ATP 合成和产热等途径的分子。本综述报告了多酚在调节有利于能量消耗调节的线粒体过程中的主要益处，并为肥胖症的管理提供了益处，特别是产热和线粒体生物发生。
