2nd Department of Cardiology, Medical School, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Department of Cardiology, "G. Gennimatas" General Hospital of Athens, Athens, Greece.
Clin Ther. 2019 Jan;41(1):21-29. doi: 10.1016/j.clinthera.2018.08.008. Epub 2018 Sep 11.
The goal of this review was to summarize, analyze, and compare trials studying the efficacy of colchicine in the prevention of atrial fibrillation (AF) post-operatively (POAF) and post-catheter ablation. Ongoing studies and current guidelines are also presented and reviewed.
Published studies on the field were identified through a literature search of the PubMed and clinicaltrials.gov databases.
Four original studies regarding POAF, two original studies regarding post-catheter ablation AF, and six meta-analyses were identified. In addition, the 3 most recent guidelines/expert consensus documents were scrutinized.
AF occurs frequently after cardiac surgery (POAF) and catheter pulmonary vein isolation (postablation AF) and is associated with increased cardiovascular morbidity. A number of trials over the last few years have investigated the role of colchicine in the prevention of POAF and postablation AF targeting the local and systemic inflammatory process that leads to initiation and maintenance of AF. Available data imply that colchicine may have a preventive role in POAF and/or postablation AF. However, certain limitations of these studies underline the need for further investigation.
本综述的目的是总结、分析和比较研究秋水仙碱预防术后（POAF）和导管消融后心房颤动（AF）的疗效的试验。还介绍和审查了正在进行的研究和当前的指南。
通过对 PubMed 和 clinicaltrials.gov 数据库的文献检索，确定了该领域的已发表研究。
确定了 4 项关于 POAF 的原始研究、2 项关于导管消融后 AF 的原始研究和 6 项荟萃分析。此外，还仔细审查了 3 份最近的指南/专家共识文件。
心脏手术后常发生 AF（POAF）和导管肺静脉隔离后 AF（消融后 AF），并与心血管发病率增加相关。近年来，许多试验研究了秋水仙碱在预防局部和全身炎症过程引起的 POAF 和消融后 AF 中的作用，该炎症过程导致 AF 的发生和维持。现有数据表明，秋水仙碱可能对 POAF 和/或消融后 AF 具有预防作用。然而，这些研究的某些局限性强调了需要进一步研究。
